Choroidal Mass in a Patient with Undiagnosed Pulmonary Langerhans' Cell Histiocytosis.

Background: Langerhan cell histiocytosis (LCH), although not a common cause, should be kept in the differential diagnosis for a patient that presents with a choroidal mass.

Case Presentation: A 28-year-old female presented with a 4-day history of vision loss and associated pain in her right eye.

Examination And Investigations: A dilated fundus examination revealed a deep subretinal, orange, mottled lesion with associated serous retinal detachment.

Multifocal melanoma of the conjunctiva in an African American patient with neurofibromatosis type 1.

A 22-year-old African American female with neurofibromatosis type 1 and multifocal conjunctival melanoma with scleral invasion. The lesion was detected during pregnancy, and after early induction of childbirth, staging by sentinel lymph node biopsy and imaging studies were performed. Systemic evaluation was negative, and the patient was treated with excisional biopsy and cryotherapy.

Biocompatible reverse thermal gel sustains the release of intravitreal bevacizumab in vivo.

Purpose: We assessed the in vivo release profile of bevacizumab from and biocompatibility of poly(ethylene glycol)-poly-(serinol hexamethylene urethane), or ESHU, a thermoresponsive hydrogel administered intravitreally for drug delivery.

Methods: The technical feasibility of injection was assessed quantitatively via mechanical testing. For in vivo studies, New Zealand White rabbit eyes were injected intravitreally with 0.

Radiation therapy: anterior segment complications.

The goal of radiotherapy is to produce maximal damage to the tumor yet at the same time produce minimal damage to the surrounding tissues. Here we discuss anterior chamber complications of radiotherapy. These can vary from ocular surface irritation to blindness and can be subdivided into acute (<4 weeks) and chronic (>4 weeks).

Radiation therapy: age-related macular degeneration.

Age-related macular degeneration (AMD) is the leading cause of severe irreversible vision loss in patients over the age of 50 years in the developed world. Neovascular AMD (NVAMD) is responsible for 90% of the cases with severe visual loss. In the last decade, the treatment paradigm for NVAMD has been transformed by the advent of anti-vascular endothelial growth factor therapy.

Immunological disruption of antiangiogenic signals by recruited allospecific T cells leads to corneal allograft rejection.

Corneal transplantation is the most common solid organ transplantation. The immunologically privileged nature of the cornea results in high success rates. However, T cell-mediated rejection is the most common cause of corneal graft failure.