Publications by authors named "Carlos A Mandarim"
Int J Dermatol
December 2023
Article Synopsis
- - Oral isotretinoin (ISO) is an effective medication for severe acne and shows promise in treating photoaging by remodeling collagen in the skin, providing an alternative to topical retinoic acid.
- - A study comparing skin samples from women aged 45-50 over three periods (before treatment, end of treatment, and 12 weeks post-treatment) found significant increases in collagen I and III after 12 weeks of low-dose ISO treatment.
- - Results indicate that while collagen levels increased significantly during treatment, the effects on matrix metalloproteinases (MMPs) were mixed, suggesting ISO effectively enhances collagen production but may not consistently alter all related enzymes post-treatment.
