Leukocytosis as a predictor of severe injury in blunt trauma.

Objective: The objective of this study was to determine if the white blood cell count can predict severity of injury in blunt trauma victims.

Methods: This was a retrospective study comparing two groups of blunt trauma victims by severity of injury, one with significant injury and one without significant injury, and comparing their initial WBC in the emergency department (ED). We also examined if WBC correlates with degree of injury using Injury Severity Score (ISS) in both groups combined.

Role for Spi-C in the development of red pulp macrophages and splenic iron homeostasis.

Tissue macrophages comprise a heterogeneous group of cell types differing in location, surface markers and function. Red pulp macrophages are a distinct splenic subset involved in removing senescent red blood cells. Transcription factors such as PU.