Publications by authors named "Carlo Mario"

Aim: Postoperative Atrial Fibrillation (POAF) is a common complication following Coronary Artery Bypass Grafting (CABG), associated with increased morbidity and mortality. Aim of the study is to analyze whether the measurement of preoperative Left Atrial (LA) strain can offer advantages over conventional clinical and echocardiographic parameters to identify patients at risk of developing POAF.

Methods And Results: We conducted a prospective study involving 100 patients undergoing isolated CABG from April 2023 to April 2024.

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Background: Lipoprotein(a) [Lp(a)] is associated with increased cardiovascular risk, but its influence on plaque characteristics at optical coherence tomography (OCT) evaluation is not fully understood.

Aims: This study seeks to explore the impact of Lp(a) levels on plaque morphology as assessed by OCT in a very high-risk subset of patients.

Methods: Consecutive patients admitted for acute coronary syndrome (ACS) and undergoing OCT-guided percutaneous coronary intervention (PCI) at a large tertiary care center between 2019 and 2022 were deemed eligible for the current analysis.

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Outcome data on using cangrelor in older patients are limited. This post hoc analysis of the itAlian pRospective Study on CANGrELOr (ARCANGELO) study aims to assess bleeding and ischemic outcomes with the transition from cangrelor to any oral P2Y inhibitors in age-stratified subgroups (≥75 years-older, <75 years-younger) of patients with acute coronary syndrome who underwent percutaneous coronary intervention (PCI). Of 995 patients, 215 (21.

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  • Coronary intravascular lithotripsy (IVL) is an effective method for stent implantation in severely calcified lesions, specifically those with calcified nodules (CNs).
  • In a study of 155 patients, IVL demonstrated similar outcomes in terms of stent area and expansion, regardless of the presence of CNs, even though CNs had higher calcium volume and angle.
  • The 2-year rate of target lesion failure was not significantly different between CN and non-CN lesions, suggesting that further research is needed to evaluate different treatment methods for these types of lesions.
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  • The CTO-ARC identified the need for standardized definitions in chronic total occlusion (CTO) procedures to avoid bias in attributing complications to different crossing strategies.
  • A study analyzed data from 8,673 patients in the European Registry of Chronic Total Occlusions, finding that the antegrade approach was used in 79.2% of cases, while retrograde was used in 20.8%.
  • Results showed that alternative antegrade crossing had lower technical success rates and higher complication rates compared to true antegrade and retrograde methods, though it was primarily used as a rescue strategy in most instances.
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  • The study investigates the significance of cardiac troponin (cTn) levels in predicting mortality in patients with Takotsubo syndrome (TTS), analyzing data from the International Takotsubo Registry.
  • It identifies that a cTn increase greater than 28.8 times the upper reference limit signals clinically relevant myocardial injury, correlating with a higher risk of mortality over 5 years (adjusted HR 1.58).
  • The findings enhance understanding of patient risk profiles in TTS, emphasizing the need for increased monitoring and follow-up for those with significant troponin elevations.
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  • The study investigated changes in demographics, risk factors, clinical presentations, and outcomes of takotsubo syndrome (TTS) patients from 2004 to 2021, using data from the InterTAK registry.
  • Over the years, the proportion of male patients increased, and there was a rise in cases of midventricular TTS as well as significant growth in the incidence of physical triggers.
  • There was also a notable increase in 60-day mortality rates, although no significant change in 1-year mortality when excluding early deaths was observed, indicating a complex evolution of TTS and its management in recent years.
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Improved expertise and technological advancements have enabled the safe and effective performance of complex and high-risk-indicated percutaneous coronary intervention (CHIP) in patients previously considered inoperable or high-risk. Mechanical circulatory support (MCS) devices play a crucial role in stabilizing hemodynamics during percutaneous coronary intervention (PCI) -related ischemia, thereby reducing the risk of major adverse events and achieving a more complete revascularization. However, the use of MCS devices in protected PCI is not without risks, including peri-procedural myocardial infarction (MI), bleeding, and access-related complications.

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  • Intravascular lithotripsy (IVL) is effective and safe for preparing calcified lesions before drug-eluting stent placement, particularly in women, compared to other treatment options which can lead to more complications.
  • A study analyzing data from 448 patients found that women were generally older, less likely to smoke, and had smaller and shorter lesions than men, yet resulted in similar angiographic outcomes and complication rates post-procedure.
  • Long-term results showed no significant differences in major adverse cardiac events or target lesion failure between women and men at 1 year, indicating that IVL has comparable safety and effectiveness across sexes.
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Aims: Vericiguat is a soluble guanylate cyclase stimulator and improves survival in patients with heart failure (HF) with reduced ejection fraction (HFrEF) and an increased risk of decompensation. As real-world data on how many patients could be eligible for vericiguat therapy derive from outdated registries, we aimed to assess eligibility in a prospective cohort of patients with HF.

Methods And Results: Data from consecutive HF patients undergoing an elective ambulatory visit at five university hospitals from 3 July to 28 July 2023 were collected.

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  • Bifurcation involvement in chronic total occlusion (CTO) percutaneous coronary intervention (PCI) is a significant challenge, but this factor hasn't been widely studied or included in existing scoring systems.
  • An analysis of 3,948 CTO-PCI procedures from 92 European centers revealed that 33% of these cases involved bifurcation lesions, which were generally more complex and required more sophisticated devices, resulting in higher radiation and contrast exposure.
  • Despite comparable overall technical success rates between bifurcation and non-bifurcation lesions, bifurcation lesions located within the CTO segment faced significantly lower success rates, making it crucial to consider their presence in future PCI assessments.
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  • - This study assessed if sodium-glucose cotransporter-2 inhibitors (SGLT2-i) can protect against contrast-induced acute kidney injury (CI-AKI) in heart failure patients undergoing procedures using iodinated contrast.
  • - Researchers divided participants into those using SGLT2-i and those not, measuring the occurrence of CI-AKI, overall mortality, and the need for renal therapy during hospitalization.
  • - Results showed lower CI-AKI rates in SGLT2-i users (9.3%) compared to non-users (27.3%), and the SGLT2-i group had no need for continuous renal replacement therapy, suggesting that SGLT2-i therapy offers a protective benefit in this context. *
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  • - The study explores the relationship between frailty and health status in older patients with transthyretin cardiac amyloidosis (ATTR-CA), utilizing the Kansas City Cardiomyopathy Questionnaire (KCCQ) for health assessment.
  • - Out of 168 patients screened, 138 were enrolled, revealing that 14.5% were frail and the median health status score was 66.
  • - Results indicated that factors like age and frailty level significantly impacted health status, suggesting future research could further clarify how frailty affects quality of life and prognosis in these patients.
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Background And Aims: There is significant potential to streamline the clinical pathway for patients undergoing transcatheter aortic valve implantation (TAVI). The purpose of this study was to evaluate the effect of implementing BENCHMARK best practices on the efficiency and safety of TAVI in 28 sites in 7 European countries.

Methods: This was a study of patients with severe symptomatic aortic stenosis (AS) undergoing TAVI with balloon-expandable valves before and after implementation of BENCHMARK best practices.

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In this work, the case of a 70-year-old Caucasian woman affected by cryptogenic stroke is reported. After discarding other sources of embolism, a transesophageal echocardiogram was performed, which revealed the presence of a double interatrial septum associated with a left-sided atrial pouch. The persistent interatrial space was identified as the most probable source of thrombus.

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Noninvasive imaging methods, either anatomical or functional tests, serve as essential instruments for the appropriate management of patients with established or suspected coronary artery disease (CAD). We sought to evaluate the safety and efficacy of a coronary computed tomography angiography (CCTA) plus stress cardiac magnetic resonance imaging (S-CMR) strategy in patients with chronic coronary syndrome (CCS). Patients with suspected CCS showing intermediate coronary plaques (stenosis 30-70%) at CCTA underwent S-CMR.

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  • Low operator and institutional volume in percutaneous coronary interventions (PCI) can lead to worse outcomes for patients, prompting this study to assess the link between operator experience and procedural success in chronic total occlusion (CTO) cases.
  • The study analyzed data from nearly 15,000 CTO-PCIs performed between 2014 and 2020, finding that higher annual caseloads per operator correlated with better procedural success rates and fewer complications.
  • Results indicated that operators performing around 40 CTO cases annually had the best outcomes, suggesting that increasing experience could enhance the quality of treatments in PCI.
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Chronic total occlusion (CTO) percutaneous coronary intervention (PCI) continues to evolve. This review summarizes recent publications categorized by outcomes, techniques, complications, and ongoing studies in this rapidly growing area.

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Transcatheter aortic valve replacement performed in patients with previously implanted mechanical mitral prosthesis represents a high risk procedure with several potential complications. We report a systematic use of a prediction model based on artificial intelligence to plan the interventional strategy in this challenging scenario.

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Chronic total occlusions (CTOs) of coronary arteries can be found in the context of chronic or acute coronary syndromes; sometimes they are an incidental finding in those apparently healthy individuals undergoing imaging for preoperative risk assessment. Recently, the invasive management of CTOs has made impressive progress due to sophisticated preinterventional assessment, including advanced non-invasive imaging, the availability of novel and dedicated tools for CTO percutaneous coronary intervention (PCI), and experienced interventionalists working in specialised centres. Thus, it is crucial that referring physicians who see patients with CTO be aware of recent developments and of the initial evaluation requirements for such patients.

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Background: Percutaneous coronary interventions (PCI) of chronic total occlusions (CTO) have reached high procedural success rates thanks to dedicated equipment, evolving techniques, and worldwide adoption of state-of-the-art crossing algorithms.

Aims: We report the contemporary results of CTO PCIs performed by a large European community of experienced interventionalists. Furthermore, we investigated the impact of different risk factors for procedural major adverse cardiac and cerebrovascular events (MACCE) and trends of employment of specific devices like dual lumen microcatheters, guiding catheter extensions, intravascular ultrasound and calcium-modifying tools.

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