Publications by authors named "Carlo Alberto Sepich"
Introduction: The aim of the study was to evaluate if and when the presence of radiological urinary leakages of vesico-urethral anastomosis, after robotic radical prostatectomy, could provoke urethral strictures or affect continence recovery.
Methods: We enrolled 216 patients, undergoing robot-assisted radical prostatectomy between January 2020 and December 2022 in three high-volume referenced centres for robotic surgery. Before removal of the bladder catheter, all patients underwent a cystourethrography in which the presence/absence of leakage was assessed at level of vesico-urethral anastomosis.
Treatment of 2-4 cm kidney stones: multicentre experience. Comparison of safety, efficacy, and costs of percutaneous nephrolithotomy and retrograde intrarenal surgery.
Cent European J Urol
April 2023
Introduction: The objective of this study is to compare the safety and efficacy, through the stone-free rate (SFR), as well as the costs, between retrograde intrarenal surgery (RIRS) and percutaneous nephrolithotomy (PCNL), for 2-4 cm kidney stones.
Material And Methods: We analysed the data relating to RIRS and PCNL performed in 3 reference centres for kidney stones, in the period between 1/2019 and 12/2021. The total number of procedures was 130 (63 RIRS and 67 PCNL).
Objective: To study and analyze any correlations between positive surgical margins after RARP and biochemical recurrence.
Methods: We enrolled 105 patients who underwent robot-assisted radical prostatectomy (RARP) from 2016-2020 with PSMs on final pathology, all performed or supervised by a senior surgeon in two tertiary referral center. Pathology has been described indicating also the area (apical, base, mediolateral, anterior, or multiple) and the extent of PSMs: focal (≤3 mm) or extensive (>3 mm).
Introduction: An important issue in robotic surgery is the training of urologists and the learning curve to perform a robot-assisted partial nephrectomy (RAPN), especially for those procedures that require vascular clamping.
Material And Methods: We retrospectively enrolled 333 patients, undergoing RAPN in the period between 01/2014 and 12/2020. Surgical complexity, surgery duration, perioperative complications, and clamping were evaluated for each patient.
Article Synopsis
- - Bladder cancer is a major global health issue, with low grade tumors making up 70% of cases, while high grade tumors are more aggressive and resistant to treatment; a major goal is to identify biomarkers that can predict tumor progression.
- - This study analyzed the mutational status and gene expression of several markers in 66 bladder cancer cases, finding that Survivin is linked to tumor grade and correlated with CD44, particularly in high grade tumors.
- - The findings suggest that Survivin could serve as a valuable biomarker for high grade bladder cancer and may represent a potential new target for therapies, especially in cases without TP53 mutations.