Publications by authors named "Carlien A Bennebroek"
Article Synopsis
- Progressive isolated optic nerve glioma (ONG) in children is a rare condition with no standard treatment consensus, and a study was conducted to compare the effectiveness of different treatment methods.
- The study involved 21 ONGs where systemic anticancer therapy (SAT) led to visual improvements in a significant number of cases, while surgery often resulted in worsening vision, and radiotherapy had mixed effects, including a potential increase in tumor volume shortly after treatment.
- The findings suggest that SAT is the preferred treatment for preserving vision, while surgery may help alleviate other symptoms in blind patients, but radiotherapy poses risks and needs careful evaluation before use.
Purpose: Progressive pediatric optic pathway gliomas (OPGs) are treated by diverse systemic antitumor modalities. Refined insights on the course of intra-tumoral components are limited.
Methods: We performed an exploratory study on the longitudinal volumetric course of different (intra-)tumor components by manual segmentation of MRI at the start and after 3, 6 and 12 months of bevacizumab (BVZ) treatment.
Tocilizumab for the fifth progression of cystic childhood craniopharyngioma-a case report.
Front Endocrinol (Lausanne)
October 2023
We present the case of a 15-year-old girl, with a fifth cystic progression of an adamantinomatous craniopharyngioma after multiple surgeries and previous local radiotherapy. She had severe visual impairment, panhypopituitarism including diabetes insipidus, and several components of hypothalamic damage, including morbid obesity and severe fatigue. To prevent further late effects hampering her quality of survival, she was treated biweekly with intravenous tocilizumab, an anti-interleukin-6 agent, which stabilized the cyst for a prolonged time.
View Article and Find Full Text PDFA prospective multicentre randomized placebo-controlled superiority trial in patients with suspected bacterial endophthalmitis after cataract surgery on the adjuvant use of intravitreal dexamethasone to intravitreal antibiotics.
Acta Ophthalmol
June 2018
Purpose: We aimed to determine whether intravitreal dexamethasone as an adjuvant to intravitreal antibiotics is beneficial in the treatment of suspected bacterial endophthalmitis after cataract surgery.
Methods: Randomized, placebo-controlled superiority trial in three tertiary referral centres in the Netherlands. Patients with suspected bacterial endophthalmitis within 6 weeks after cataract surgery were eligible.
Unlabelled: This report describes a novel mutation of LAMB2, the gene associated with Pierson syndrome (microcoria-congenital nephrosis syndrome), in two female siblings. The c.970T>C p.
View Article and Find Full Text PDFA prospective multicenter randomized placebo-controlled trial of dexamethasone as an adjuvant in the treatment of postoperative bacterial endophthalmitis: interim safety analysis of the study drug and analysis of overall treatment results.
Graefes Arch Clin Exp Ophthalmol
October 2014
Purpose: In an ongoing prospective multicenter randomised placebo-controlled trial we study the adjuvant use of intravitreal dexamethasone in the treatment of patients with suspected bacterial endophthalmitis after phacoemulsification. In accordance with the study protocol, a mid-inclusion interim analysis of the safety of the study drug was performed.
Patients And Methods: Patients with suspected endophthalmitis after phacoemulsification were asked to participate in this study.