Publications by authors named "Carliani Dal Piero Betzel Bessa"
Article Synopsis
- Chagas disease and leishmaniasis are widespread in Latin America, and current treatments are insufficient, making natural products, particularly from the Amaryllidaceae family, promising for developing new therapies due to their antiparasitic alkaloids.
- The study aimed to test the anti-parasitic effects of five natural isoquinoline alkaloids isolated from Hippeastrum aulicum against different stages of Trypanosoma cruzi and Leishmania infantum, using both in silico and in vitro methods, as well as molecular docking techniques.
- Results indicated that haemanthamine and lycorine were the most effective against both parasites, with additional promising activity shown by 7-methoxy-O-m
