Reversal of PAP Failure With the REPAP Protocol.

Background: Re-titrations, an atypical approach to reverse PAP failure, was investigated retrospectively.

Methods: Application of our re-titration of PAP (REPAP) protocol in subjects with previous PAP failure assessed original technology (masks, modes, and pressures) in 273 subjects, of which 70% reported co-occurring psychiatric conditions. The REPAP protocol emphasized changes in pressure modes and settings to address expiratory pressure intolerance and residual breathing events; mask changes were facilitated.