Objective: To evaluate the efficiency of oocyte donation cycles using egg "cryo-banking."
Design: Study conditions for vitrified/warmed oocytes for 20 non-autologous recipients (from 10 donors) were set prospectively, and outcomes of it were later compared retrospectively to nine fresh donations cycles.
Setting: Private assisted reproductive technology program.
Purpose: A major gene responsible for the control of preimplantation cleavage rate is the Ped gene, the product of which is the Qa-2 protein. Fast, but not slow developing mouse embryos express the Qa-2 protein. Platelet-activating factor (PAF) is a novel and potent signaling phospholipid that has unique pleiotropic properties in addition to platelet activation.
View Article and Find Full Text PDFObjective: To determine the relationship between platelet-activating factor acetylhydrolase (PAFah) content in semen and sperm motility.
Design: The PAFah levels in semen were measured and correlated with sperm motility.
Setting: Clinical laboratory in a private assistant reproductive technology clinic.
Body mass index (BMI) has been demonstrated to affect female fertility; however, little information is available on the impact of BMI on male fertility or semen parameters. Therefore, the study objective was to determine the relationship between BMI and semen parameters, including sperm chromatin integrity. We analyzed data on semen samples from 520 men who were grouped based upon calculated BMI values (normal, 20-24 kg/m(2); overweight, 25-30 kg/m(2); obese, >30 kg/m(2)).
View Article and Find Full Text PDFSince its discovery nearly 30 years ago platelet-activating factor (PAF) has emerged as one of the more important lipid mediators known. PAF (1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphorylcholine) exists endogenously as a mixture of molecular species with structural variants of the alkyl moiety. PAF is a novel potent signaling phospholipid that has unique pleiotropic biological properties in addition to platelet activation.
View Article and Find Full Text PDFProblem: Platelet-activating factor (PAF) plays a significant role in fertility. Preimplantation stage embryos produce PAF (ePAF) which is required for development. PAF's mechanism of action is receptor-mediated and its presence has been reported in the developing mouse and human embryo.
View Article and Find Full Text PDFObjective: To determine the efficacy of treating semen specimens with platelet-activating factor (PAF) before IUI.
Design: Prospective randomized double-blinded study of PAF treatment of sperm for patients with a history of infertility undergoing IUI.
Setting: Private infertility center.
Purpose: Platelet-activating factor (PAF) is a potent signaling phospholipid that is found in mammalian sperm and has a positive correlation with fertility. Whereas PAF is present in human sperm, there are no relational reports on its content and the cells fertilization potential. Therefore, the study objective was to determine if PAF content in capacitated-induced sperm is related to fertilization potential as determined by the sperm penetration assay (SPA).
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