Enhancing Health Literacy: Evaluating the Readability of Patient Handouts Revised by ChatGPT's Large Language Model.

Objective: To use an artificial intelligence (AI)-powered large language model (LLM) to improve readability of patient handouts.

Study Design: Review of online material modified by AI.

Setting: Academic center.

Sinonasal Symptom Correlation With the Postoperative Polyp Scale (POPS).

Background: Commonly used endoscopic nasal polyp grading scales have been shown to correlate poorly with symptom scores and quality of life metrics. The recently described Postoperative Polyp Scale (POPS) is a grading system that more accurately characterizes polyp recurrence in postoperative sinus cavities by describing incremental recurrence in relation to the surgically opened sinus cavities.

Objective: The objective of this study was to determine if the POPS correlated with sinonasal symptoms.

A combination of three antioxidants decreases the impact of rural particulate pollution in Normal human keratinocytes.

Objective: It is well established that exposure of human skin to airborne pollution, particularly in the form of particulate matter sized 2.5 μm (PM ), is associated with oxidative stress, DNA damage and inflammation, leading to premature signs of skin aging. Because much of the damage results from oxidative stress, we examined the effects of a topical composition containing three antioxidants in an in vitro model system to assess the potential for amelioration of premature aging.

Retrospective cohort study rethinking lip reconstruction: Versatility of the depressor anguli oris myocutaneous flap for large full-thickness defects.

Background: Large full-thickness lip defects present a reconstructive challenge.

Objective: To describe the impact on clinical outcomes and institutional cost of the depressor anguli oris myocutaneous (DAOM) flap as an axial pattern transposition flap for reconstruction of large, full-thickness lip defects.

Methods: A multicenter retrospective cohort study of adults with large full-thickness lip defects who underwent DAOM flap reconstruction from 2011 to 2018 was conducted.

Superior Hypogastric Nerve Blockade for Uterine Artery Embolization: A Systematic Review.

Superior hypogastric nerve block (SHNB) has potential to reduce pain following uterine artery embolization (UAE). However, existing studies are limited by design, sample size, or conflicting results. A systematic review of the literature was performed.

Isolation of circulating tumor cells to diagnose melanoma and evaluate the efficacy of surgical resection using melanoma-specific microsystem.

Melanoma is one of the most aggressive skin cancers due to its potential to metastasize widely in the body. The risk of metastasis is increased with later detection and increased thickness of the primary lesion, thus early identification and surgical removal is critical for higher survival rates for patients. However, even with appropriate treatment, some patients will develop recurrence which may be difficult to identify until advanced or causing symptoms.

Modified Endoscopic Denker's Approach for Management of Anterior Maxillary Sinus Tumors: Multicenter Series of 58 Cases.

Objectives: Tumors involving the anterior portion of the maxillary sinus remain technically challenging to access via an endoscopic approach. The modified endoscopic Denker's (MED) procedure was recently introduced to address such lesions. We present a multicenter series of 58 patients with tumors involving the anterior maxillary sinus successfully resected using a MED procedure and present the clinical outcomes and complications.

A of Effects of Environment on Brain Size in Insects.

Brain size fascinates society as well as researchers since it is a measure often associated with intelligence and was used to define species with high "intellectual capabilities". In general, brain size is correlated with body size. However, there are disparities in terms of relative brain size between species that may be explained by several factors such as the complexity of social behaviour, the 'social brain hypothesis', or learning and memory capabilities.

Sinonasal Symptom Outcomes following Endoscopic Anterior Cranial Base Surgery in the Pediatric Population.

 This study aimed to evaluate the impact of endoscopic anterior cranial base (ACB) surgery on sinonasal symptoms in the pediatric population utilizing the Sino-Nasal Outcome Test (SNOT)-22 questionnaire.  This is a retrospective review.  The study was conducted at a tertiary academic medical center.

Assessment of Biomarker Heterogeneity in Sinus Versus Inferior Turbinate Tissue in Patients Without Chronic Rhinosinusitis.

Background: Currently, no consensus exists on the appropriate control specimen site to utilize in studies evaluating for biomarkers in chronic rhinosinusitis (CRS). Studies thus far have utilized tissue from various anatomic sites despite regional heterogeneity.

Objective: We set out to quantify the differences in biomarker levels present in inferior turbinate versus sphenoid sinus mucosa in paired healthy control patients.

Aldehyde-specific responses of olfactory sensory neurons in the praying mantis.

Although praying mantises rely mainly on vision for predatory behaviours, olfaction also plays a critical role in feeding and mating behaviours. However, the receptive processes underlying olfactory signals remain unclear. Here, we identified olfactory sensory neurons (OSNs) that are highly tuned to detect aldehydes in the mantis Tenodera aridifolia.

Correction: Back to the light, coevolution between vision and olfaction in the "Dark-flies" (Drosophila melanogaster).

[This corrects the article DOI: 10.1371/journal.pone.

Back to the light, coevolution between vision and olfaction in the "Dark-flies" (Drosophila melanogaster).

Trade-off between vision and olfaction, the fact that investment in one correlates with decreased investment in the other, has been demonstrated by a wealth of comparative studies. However, there is still no empirical evidence suggesting how these two sensory systems coevolve, i.e.

Effect of Light Exposure upon Food Consumption and Brain Size in Dark-Flies (Drosophila melanogaster).

While reducing the investment in the visual system of nocturnal/cave-dwelling species appears to be an evolutionarily stable strategy in response to the difficulty of locating food in the dark, relying on visual information for diurnal species is crucial for their survival and reproduction. However, the manner in which species evolve and adapt to the energetic demands placed upon them by environmental changes is not perfectly understood. In particular, if life in the dark is associated with a reduction in energetic demand, would relocation to a well-lit environment increase energetic demand? This question has a bearing upon our understanding of factors that influence the ability of species to adapt to new habitats.

Optimal Timing of Entry-Level Otolaryngology Simulation.

Objective: Appropriate timing of subspecialty simulation is critical to maximize learner benefit and guide resource utilization. We aimed to determine optimal timing of a simulation-based curriculum designed to teach entry-level procedural skills for otolaryngology residency.

Study Design: Simulation curriculum intervention tested among 3 comparison groups of varying clinical levels.

Aversive Learning in the Praying Mantis (), a Sit and Wait Predator.

Animals learn to associate sensory cues with the palatability of food in order to avoid bitterness in food (a common sign of toxicity). Associations are important for active foraging predators to avoid unpalatable prey and to invest energy in searching for palatable prey only. However, it has been suggested that sit-and-wait predators might rely on the opportunity that palatable prey approach them by chance: the most efficient strategy could be to catch every available prey and then decide whether to ingest them or not.

Organization of the antennal lobes in the praying mantis (Tenodera aridifolia).

Olfaction in insects plays pivotal roles in searching for food and/or for sexual partners. Although many studies have focused on the olfactory processes of nonpredatory insect species, little is known about those in predatory insects. Here, we investigated the anatomical features of the primary olfactory center (antennal lobes) in an insect predator whose visual system is well developed, the praying mantis Tenodera aridifolia.

Dispatcher Stroke Recognition Using a Stroke Screening Tool: A Systematic Review.

Background: Emergency dispatchers represent the first point of contact for patients activating an acute stroke response. Accurate dispatcher stroke recognition is associated with faster emergency medical services response time; however, stroke is often unrecognized during initial emergency calls. Stroke screening tools such as the Cincinnati Prehospital Stroke Scale have been shown to improve on-scene stroke recognition and thus have been proposed as a means to improve dispatcher accuracy.

Antennal development in the praying mantis (Tenodera aridifolia) highlights multitudinous processes in hemimetabolous insect species.

Insects possess antennae equipped with a large number of segments (flagellomeres) on which sensory organs (sensilla) are located. Hemimetabolous insects grow by molting until they reach adulthood. In these species, the sensory structures develop and mature during each stage of development; new flagellomeres are generated at each molt elongating the antennae, and new sensilla appear.

The antennal sensilla of the praying mantis Tenodera aridifolia: a new flagellar partition based on the antennal macro-, micro- and ultrastructures.

In insects, the antenna consists of a scapus, a pedicellus, and a flagellum comprising many segments (flagellomeres). These segments possess many morphological types of sensory organs (sensilla) to process multimodal sensory information. We observed the sensilla on flagellomeres in praying mantis (Tenodera aridifolia) with both scanning and transmission electron microscopes.

Complete set of operational measures for the characterization of three-qubit entanglement.

We characterize the entanglement contained in a pure three-qubit state via operational entanglement measures. To this end, we derive a new decomposition for arbitrary three-qubit states which is characterized by five parameters (up to local unitary operations). We show that these parameters are uniquely determined by bipartite entanglement measures.

Cold-induced disruption of Na+ channel slow inactivation underlies paralysis in highly thermosensitive paramyotonia.

The Q270K mutation of the skeletal muscle Na(+) channel alpha subunit (Nav1.4) causes atypical paramyotonia with a striking sensitivity to cold. Attacks of paralysis and a drop in the compound muscle action potential (CMAP) are exclusively observed at cold.

Altered sensitivity to rewarding and aversive drugs in mice with inducible disruption of cAMP response element-binding protein function within the nucleus accumbens.

The transcription factor cAMP response element-binding protein (CREB) within the nucleus accumbens (NAc) plays an important role in regulating mood. In rodents, increased CREB activity within the NAc produces depression-like signs including anhedonia, whereas disruption of CREB activity by expression of a dominant-negative CREB (mCREB, which acts as a CREB antagonist) has antidepressant-like effects. We examined how disruption of CREB activity affects brain reward processes using intracranial self-stimulation (ICSS) and inducible bitransgenic mice with enriched expression of mCREB in forebrain regions including the NAc.

Delta FosB mediates epigenetic desensitization of the c-fos gene after chronic amphetamine exposure.

The molecular mechanisms underlying the transition from recreational drug use to chronic addiction remain poorly understood. One molecule implicated in this process is DeltaFosB, a transcription factor that accumulates in striatum after repeated drug exposure and mediates sensitized behavioral responses to psychostimulants and other drugs of abuse. The downstream transcriptional mechanisms by which DeltaFosB regulates drug-induced behaviors are incompletely understood.