[Distal osteotomy of the first metatarsal bone with plantarization for the treatment of hallux limitus due to metatarsus primus elevatus].

Objective: Joint-preserving procedure with plantarization of the 1st metatarsal and improvement of range of motion.

Indications: Mild and moderate arthrosis of the 1st metatarsophalangeal joint with pain and shoe discomfort due to elevation of 1st ray and failed conservative treatment.

Contraindications: Severe degenerative conditions 1st metatarsophalangeal joint with significant loss of range of motion preoperatively.

[Memory of policies and practices in harm reduction: an interview with Fatima Machado].

This interview addresses the trajectory of harm reduction policies and practices in Brazil, in the words of harm reducer Fatima Machado. Harm reduction emerged in the 1980s in Europe, it began in Brazil in 1989 as a strategy to prevent aids among injection drug users, and then diversified and expanded. This interview focuses on the early years of developing these innovative practices and questions their current developments.

Risk Analysis of Nonunion After First Metatarsophalangeal Joint Arthrodesis.

The standard therapy for a symptomatic hallux rigidus is still the arthrodesis of the first metatarsophalangeal (MTP) joint. A nonunion of the arthrodesis is a possible postoperative complication. This study aimed to evaluate the incidence of nonunion associated with first MTP joint arthrodesis and identify risk factors influencing this.

Taraxerol as a possible therapeutic agent on memory impairments and Alzheimer's disease: Effects against scopolamine and streptozotocin-induced cognitive dysfunctions.

Alzheimer's disease (AD) is a neurodegenerative disorder associated with cognitive impairment and cholinergic neuronal death, characteristic of the effect of time on biochemical neuronal function. The use of medicinal plants as an alternative form of prevention, or even as a possible treatment of AD, is therefore interesting areas of research, since the standard drugs have many side effects. Taraxerol (TRX) is a triterpene that has been isolated from several plant species, and its various pharmacological properties have already been identified, such the acetylcholinesterase (AChE) inhibition activity in vitro.

Applying Adult Ventilator-associated Pneumonia Bundle Evidence to the Ventilated Neonate.

Background: Ventilator-associated pneumonia (VAP) in neonates can be reduced by implementing preventive care practices. Implementation of a group, or bundle, of evidence-based practices that improve processes of care has been shown to be cost-effective and to have better outcomes than implementation of individual single practices.

Purpose: The purpose of this article is to describe a safe, effective, and efficient neonatal VAP prevention protocol developed for caregivers in the neonatal intensive care unit (NICU).