Publications by authors named "Carla Simonetto"
Article Synopsis
- Dengue is the world's most common viral disease transmitted by insects, caused by four different dengue virus types (DENV-1 to DENV-4), and can lead to severe illness after sequential infections.
- Researchers developed a mouse model to study severe dengue disease using strains that are not adapted for mice, showing that prior infection with DENV-1 followed by DENV-2 leads to serious health issues like low platelet counts and internal bleeding.
- The study found that cross-reactive CD8 T lymphocytes from DENV-1 infections play a crucial role in causing severe symptoms during secondary infections, linked to increased levels of a cytokine called tumor necrosis factor (TNF)-α.
