Publications by authors named "Carla S Moreira"
Background: Autoimmune thyroid disease (AITD) comprises diseases including Hashimoto's thyroiditis and Graves' disease, both characterized by reactivity to autoantigens causing, respectively, inflammatory destruction and autoimmune stimulation of the thyroid-stimulating hormone receptor. AITD is the most common thyroid disease and the leading form of autoimmune disease in women. Cytokines are key regulators of the immune and inflammatory responses; therefore, genetic variants at cytokine-encoding genes are potential risk factors for AITD.
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- The study investigates the link between a genetic variation in the SEPS1 gene and the risk of developing Hashimoto's thyroiditis (HT), focusing on a specific single-nucleotide polymorphism (rs28665122).
- A case-control study was conducted with 997 participants, including 481 patients with HT and 516 controls, revealing a significant association between certain genetic genotypes and a higher likelihood of HT.
- Results indicate that carriers of the A allele of SEPS1 have an increased risk, especially among male patients, suggesting that selenoproteins may play a role in autoimmune thyroid diseases.