Publications by authors named "Carla S A Baltazar"
Hydrogenases are efficient biocatalysts for H production and oxidation with various potential biotechnological applications.[NiFe]-class hydrogenases are highly active in both production and oxidation processes-albeit primarily biased to the latter-but suffer from being sensitive to O.[NiFeSe] hydrogenases are a subclass of [NiFe] hydrogenases with, usually, an increased insensitivity to aerobic environments.
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- * This enzyme is part of a subgroup where selenium replaces sulfur in the active site's nickel coordination, and the research focuses on how this substitution affects catalytic properties.
- * Findings indicate that the protein structure surrounding the active site creates a "cage effect," influencing how hydrogen and deuterium substrates interact, which is supported by simulations showing varying substrate accumulation.
Hydrogenases are metalloenzymes that catalyze the reversible reaction H(2)<->2H(+) + 2e(-), being potentially useful in H(2) production or oxidation. [NiFeSe] hydrogenases are a particularly interesting subgroup of the [NiFe] class that exhibit tolerance to O(2) inhibition and produce more H(2) than standard [NiFe] hydrogenases. However, the molecular determinants responsible for these properties remain unknown.
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