Publications by authors named "Carla Ruscio"
Fifty-three patients with multiple myeloma (MM) underwent an allogeneic stem cell transplant (HSCT) from their HLA identical siblings using a reduced-intensity conditioning consisting of thioteopa 5 mg/kg, fludarabine 90 mg/m(2), and melphalan 80 mg/m(2). Their median age was 52 years (range 38 - 68) and the interval from diagnosis 12 months. Forty-three patients (82%) had advanced disease and 33 had previously been treated with high-dose therapy with one (N = 21), or more (N = 12) autologus transplants.
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- Idiopathic hypereosinophilic syndrome (HES) is a rare blood disorder with long-lasting high eosinophil levels that can lead to organ damage, and treatments can include steroids and imatinib.
- A young male patient had severe heart issues due to HES and showed significant improvement after using imatinib, leading to a potential heart transplant consideration.
- Sadly, the patient later died from a cerebral hemorrhage related to severe respiratory issues, showcasing the unpredictability of HES and its treatment outcomes.
Plasmacytomas of the testis are rare neoplasias; they may occur as isolated tumors or in concomitance with generalized multiple myeloma. We report the case of a 77-year-old man with previous clinical evidence of multiple myeloma involving skin, ribs, and lungs, and initially treated with surgery, radiotherapy, and chemotherapy attaining partial response. Fourteen months after the onset, the patient presented with left testicular enlargement due to plasmacytoma.
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