Publications by authors named "Carla R Zeballos Torrez"
Aims: Ficolin 3 (FCN3) has the highest complement-activating capacity through the lectin pathway and is synthesized mainly in the liver and lung. Yet, its potential molecular mechanism in hepatocarcinogenesis is not fully understood.
Materials And Methods: The expression of FCN3 in hepatocellular carcinoma (HCC) tumor and non-tumor tissues was analyzed by RT-qPCR, Western blotting and immunofluorescence staining assays.
Background: The incidence and mortality rates of hepatocellular carcinoma among Hispanic individuals in the United States are much higher than in non-Hispanic White people. We conducted multi-omics analyses to elucidate molecular alterations in hepatocellular carcinoma among Hispanic patients.
Methods: Paired tumor and adjacent nontumor samples were collected from 31 Hispanic hepatocellular carcinomas in South Texas for genomic, transcriptomic, proteomic, and metabolomic profiling.
Article Synopsis
- - The study investigates the heightened rates of hepatocellular carcinoma (HCC) among Hispanics in the U.S. by analyzing tumor and adjacent non-tumor samples from Hispanic patients in South Texas through comprehensive multi-omics approaches.
- - Key findings include high mutation frequencies related to the Wnt/β-catenin pathway and the identification of HCC subtypes, where one subtype showed better survival rates associated with immune activity and lower liver function-related gene activity.
- - The research aims to provide insights into specific molecular features and potential biomarkers for HCC among Hispanic patients, laying groundwork for improved therapeutic strategies.
Article Synopsis
- A study found that Black women have a much higher chance of dying from breast cancer than White women, and it looks at how well a low-income community in West Philadelphia understands screening for it.
- They gave out surveys at a free mobile mammogram event to see what challenges women face in getting screened and to collect information about their health coverage.
- The results showed that many women struggle with costs and lack of insurance, especially those under 50; they also found that having a primary care doctor can help speed up follow-up care after screening.