Publications by authors named "Carla Piqueras"
Nat Struct Mol Biol
October 2024
Article Synopsis
- XIST long noncoding RNA plays a key role in X chromosome inactivation in placental mammals but is present on both X chromosomes in early human embryos without silencing them.
- XACT lncRNA accumulates alongside XIST on active X chromosomes and may counteract XIST's functions.
- Research using human embryonic stem cells reveals that XIST modifies chromatin and reduces transcription of X-linked genes, while XACT's absence does not significantly impact XIST’s activity or gene expression, indicating that XIST has a role prior to XCI and highlights a mechanism of temporary X chromosome dosage compensation.
