Publications by authors named "Carla Musa"
Article Synopsis
- The nuclear lamina components, previously thought to just provide structure to the nucleus, are now linked to various diseases like cancer due to their mutations and misregulation.
- Research shows that higher levels of Lamin A/C are associated with lower survival rates in glioblastoma multiforme (GBM) patients from The Cancer Genome Atlas.
- In experiments, increased Lamin A/C expression was found to enhance tumor aggressiveness, and the mTORC2 component Rictor is identified as a key player in this process.
The identification of liquid biomarkers remains a major challenge to improve the diagnosis of melanoma patients with brain metastases. Circulating miRNAs packaged into tumor-secreted small extracellular vesicles (sEVs) contribute to tumor progression. To investigate the release of tumor-secreted miRNAs by brain metastasis, we developed a xenograft model where human metastatic melanoma cells were injected intracranially in nude mice.
View Article and Find Full Text PDFThe mouse neuroblastoma N18TG2 clone is unable to differentiate and is defective for the enzymes of the biosynthesis of neurotransmitters. The forced expression of choline acetyltransferase (ChAT) in these cells results in the synthesis and release of acetylcholine (Ach) and hence in the expression of neurospecific features and markers. To understand how the expression of ChAT triggered neuronal differentiation, we studied the differences in genome-wide transcription profiles between the N18TG2 parental cells and its ChAT-expressing 2/4 derived clone.
View Article and Find Full Text PDFArticle Synopsis
- Tumor-initiating cells are a special kind of cell in tumors that act like normal stem cells and are often the reason treatments don’t work well.
- Scientists found that removing a protein called Lamin A/C from neuroblastoma (a type of cancer) cells makes them more aggressive and helps them look and act more like stem cells.
- In the study, they showed that when Lamin A/C is knocked down, the cancer cells change and grow more tumor-initiating cells, which is linked to a gene called MYCN that helps these cells survive.