The concepts of post-stroke depression and vascular depression have emphasized the bidirectional etiologic links that may connect depression and cardiovascular risk factors. In post-stroke depression, the pathogenic role of a chronic cumulative "burden" of subcortical lesions has been well established. In what concerns late-onset depression and the symptomatic profile attributed to "vascular depressions, and despite a growing body of evidence from both neuroimaging and neuropathologic studies, this bilateral causality is still matter of debate.
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