Berberine-fluconazole microparticle-based combination therapy to treat candidiasis infections.

Aim: This study aims to incorporate alginate microparticles containing berberine and fluconazole into two different types of pharmaceutical formulations, to subsequently evaluate the antifungal activity against Candida albicans.

Methods And Results: Alginate microparticles containing BBR (berberine) and FLU (fluconazole) were produced by the spray-drying technique, characterized and incorporated in two pharmaceutical formulations, a vaginal cream and artificial saliva. Broth microdilution, checkerboard, time-kill curve, and scanning electron microscopy were carried out to determine the antifungal effects of BBR and FLU against C.

Cytotoxicity and anti-inflammatory activities of (Phytolaccaceae) fruit essential oil.

The chemical composition of fruits essential oil was obtained by hydrodistillation using a modified Clevenger apparatus was investigated by gas chromatography coupled to mass spectrometry (GC/MS). In addition, the cytotoxicity activity against human tumor cell lines MCF-7 (breast adenocarcinoma), NCI-H460 (large cell lung carcinoma), HeLa (cervical carcinoma), and HepG2 (hepatocellular carcinoma), and non-tumor PLP2 (porcine liver primary cells) as well as the anti-inflammatory action was proposal. The compounds were predominantly organosulfates (2,8-dithianonane, dimethyl trisulfide, and lenthionine).

Screening of six medicinal plant species for antileishmanial activity.

This study is aimed to investigate the anti-leishmanial activity of ethanolic, aqueous or dichloromethane extracts of leaves, flowers, fruits or roots, of six medicinal plant species, namely, , , , , and . After isolation and analysis of chemical components by ultra-high performance liquid chromatography-high-resolution tandem mass spectrometry (UHPLC-HRMS/MS), the extracts were also tested for toxicity in J774.A1 macrophages and human erythrocytes.

Larvicidal activity of extracts on larvae.

The aim of this study was to evaluate the chemical composition and the larvicidal activity of leaf and flower extracts against larvae. Twenty-four compounds were found in the leaf extract, and the major compounds were phytol (23.1%), 9,12,15-octadecatrienoic acid, ethyl ester (21.

(Mart.) O. Berg essential oil induces antileishmanial activity and remodeling of the cytoplasm organelles.

Leishmaniasis is a neglected disease that affects millions of people worldwide. This study aimed to analyze antileishmanial activity of leaf essential oil (EO) on promastigote and amastigote forms of , cytotoxicity in murine macrophages and sheep erythrocytes. The essential oil (EO) was analyzed by gas chromatography/mass spectrophotometry.

Chemical composition of (Rose) D.R. Hunt var. Boom (Commelinaceae) essential oil.

is a herbaceous plant with promising compounds in its composition that can be applied in several areas such as agronomic, pharmaceutical and chemical. However, further studies on this plant are needed in order to characterise it phytochemically, pharmacologically and toxicologically. In this sense, the present study aimed to verify the unprecedented identification of its essential oil (EO) components.

Ginger essential oil and fractions against Mycobacterium spp.

Ethnopharmacological Relevance: Zingiber officinale (ginger) is a perennial herbaceous plant native in tropical Asia and generally cultivated in most American tropical countries with widespread use in popular medicine. Ginger essential oil (GEO) has been reported to exhibit several biological activities, such as antimicrobial.

Aims Of The Study: The aim of this study was to determine the composition and the property of GEO and related fractions against Mtb and NTM, as well as their cytotoxicity.

Antioxidant activity of and -amyrin isolated from leaves.

Brazil has a great variety of native plants which could be explored and among them guabiju () stands out. Thus, this study consisted of isolating pentacyclic triterpenes, and -amyrin from guajibu leaves, and determine the antioxidant activity.The leaves were dried, pulverized and submitted to a dynamic maceration process with ethanol 96° GL, concentrated to obtain crude leaf extract (CLE).

Essential oil and fractions isolated of Laurel to control adults and larvae of cattle ticks.

This study, was to evaluate the acaricidal effect of the essential oil (EO) and fractions (FR) obtained from leaves on () . Eight fractions were obtained, however FR1: sabinene (37.83%), β-pinene (13.

Larvicidal potential of piperovatine in the control of cattle tick.

Rhipicephalus (Boophilus) microplus is one of the most important ectoparasites in cattle breeding worldwide, causing direct and indirect losses to animals and producers. Chemical acaricides are utilized in the control of cattle tick and the increase in the development of resistance by ectoparasites makes new alternative necessary. Therefore, research studies have been carried out using bioactive molecules that are quickly degraded and that reduce poisoning to appliers and non-target organisms, environmental contamination and development of resistance.

antioxidant potential and effects of Raddi leaf extract in diabetic rats and determination of chemical composition by HPLC-ESI-MS/MS.

The present study investigated the and antioxidant potential and phytochemical composition of , which is widely used in folk medicine for various therapeutic purposes. The analyses indicated that the hydroethanolic extract (HE) had 312.50 ± 0.