A Case of Diverticular Perforation in a Young Patient with Rheumatoid Arthritis on Methotrexate.

Background. Disease-modifying antirheumatic drugs (DMARDs), such as methotrexate (MTX), are associated with gastrointestinal toxicity. MTX inhibits dihydrofolate reductase, but it is unclear if polymorphisms of the methylenetetrahydrofolate reductase (MTHFR) gene predict toxicity.

Possible association of etanercept, venous thrombosis, and induction of antiphospholipid syndrome.

Tumor necrosis factor α (TNF α ) inhibitors are commonly used for treatment of aggressive rheumatoid arthritis and other rheumatic diseases. Etanercept is one of the medications approved for treatment of rheumatoid arthritis. Though many studies have documented the safety and efficacy of these medications, evidence for adverse effects is emerging including cancer, infections, and cardiovascular disease.

A Patient with Fatal Necrotizing Fasciitis following the Use of Intra-Articular Sodium Hyaluronate Injections: A Case Report.

Introduction. Osteoarthritis, a degenerative joint disease, is a key cause of disability around the world and an ever-growing public health concern. Intra-articular hyaluronic acid viscosupplementation is used as a conservative option for osteoarthritis knee pain relief (McArthur et al.

Relationship between self-reported high-heeled shoe use and bone mineral density using quantitative ultrasound at a community health fair.

This is the first known study to examine the relationship between high-heel use and bone mineral density (BMD). Because women are disproportionately affected by osteoporosis, it is important to identify possible modifiable behaviors of women that may adversely affect bone health. Many studies have shown changes in body mechanics when wearing high-heeled shoes in comparison to normal gait.

Giant cell arteritis of the thyroid in a 69-year-old male.

We report the case of a 69-year-old Caucasian male with a histological confirmed diagnosis of giant cell arteritis (GCA) of the thyroid. To our knowledge this is the second reported case of GCA of the thyroid with a histological confirmed diagnosis. Unique to this case is that our patient did not have the simultaneous occurrence of a positive temporal artery biopsy or classic symptoms of temporal arteritis.

Etanercept and venous thromboembolism: a case series.

Introduction: The treatment with antitumor necrosis factor agents has often been associated with the induction of autoantibodies (antinuclear antibodies, anti-double stranded DNA antibodies and antiphospholipid antibodies). The clinical significance of these antibodies remains unclear, but they may predispose to antiphospholipid syndrome with thromboembolic complications. The association of etanercept with thromboembolic events has not been reported previously in the literature.