Use of L. (Asteraceae) and L. (Zingiberaceae) to treat intestinal mucositis in mice: Toxico-pharmacological evaluations.

Introduction: Several studies towards the development of an effective treatment for intestinal mucositis have been reported, since this condition represents a major problem in clinical oncology practice due to cytotoxic effects of chemotherapy. However standardized protocols and universally accepted treatment options are yet to be established.

Objectives: Given above, this study evaluated the protective effects of a mucoadhesive formulation containing both L.

Curcuminoids from L. reduced intestinal mucositis induced by 5-fluorouracil in mice: Bioadhesive, proliferative, anti-inflammatory and antioxidant effects.

Introduction: Intestinal mucositis is a frequent limiting factor in anticancer therapy and there is currently no broadly effective treatment targeted to cure this side effect.

Objective: This study aimed to evaluate the effects of a mucoadhesive formulation containing curcuminoids (MFC) from L. on the pathogenesis of 5-fluorouracil (5-FU)-induced intestinal mucositis.

Mucoadhesive formulation of L. (Asteraceae) reduces intestinal injury from 5-fluorouracil-induced mucositis in mice.

Gastrointestinal mucositis induced during cancer treatment is considered a serious dose-limiting side effect of chemotherapy and/or radiotherapy. Frequently, interruption of the cancer treatment due to this pathology leads to a reduction in cure rates, increase of treatment costs and decrease life quality of the patient. Natural products such as L.