Publications by authors named "Carla B Delprato"
Article Synopsis
- Unsaturated fatty acids (UFAs) are essential for cellular functions in animals, and imbalances can lead to various health disorders.
- Conventional methods for analyzing UFA composition involve invasive techniques, but NMR spectroscopy offers a nondestructive way to study live cells.
- Using NMR to analyze C. elegans, researchers identified significant differences in lipid composition between wild-type and mutant strains, paving the way for future studies on fatty acid regulation.
Multidrug resistance (MDR) counteracts the efficiency of sorafenib, an important first-line therapy for hepatocellular carcinoma (HCC). Sirtuins (SIRTs) 1 and 2 are associated with tumor progression and MDR. We treated 2D and 3D cultures (which mimic the features of in vivo tumors) from HCC cells with sorafenib alone or in the presence of SIRTs 1 and 2 inhibitors (cambinol or EX-527; combined treatments).
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