Publications by authors named "Carla Adriana Dos Santos"
Until 2015, polymyxin resistance was primarily attributed to chromosomal mutations. However, with the first report of mobile colistin resistance () in commensal from food animals in China, the landscape has changed. To evaluate the presence of polymyxin resistance in spp.
View Article and Find Full Text PDFDetection and genomic characterization of a multidrug-resistant Salmonella Newport co-harbouring bla, qnrB19 and mcr-9 from the diarrheic faeces of a foal.
J Glob Antimicrob Resist
December 2023
Article Synopsis
- * The research involved various methods like antimicrobial susceptibility testing, whole genome sequencing, and conjugation assays to understand the strain's resistance mechanisms and plasmid characteristics.
- * The findings reveal that strain 195_20 is resistant to multiple antibiotics and carries three significant plasmids related to its resistance genes, highlighting the risk of transmission of these resistant pathogens from animals to humans.
Article Synopsis
- * Whole genome sequencing and antimicrobial susceptibility tests reveal that the isolate (288_18) is resistant to several antibiotics and carries a 67 kb transferable plasmid with the bla gene.
- * The findings stress the need for improved surveillance to control the spread of antibiotic resistance, particularly in clinically relevant strains like Salmonella Agona.
Article Synopsis
- - A patient in Brazil was found to have a multi-drug resistant Salmonella Infantis that produces CTX-M-65.
- - Whole genome sequencing revealed that the antibiotic resistance gene (bla) is located on a pESI-like megaplasmid in this particular strain (ST32).
- - Phylogenetic analysis showed that this Brazilian isolate is closely related to similar IncFIB Salmonella Infantis strains found in food and poultry in the USA.
Background: Uropathogenic Escherichia coli (UPEC) are frequent pathogens worldwide, impacting on the morbidity and economic costs associated with antimicrobial treatment.
Objectives: We report two novel mutations associated with polymyxin-B resistance in an UPEC isolate collected in 2019.
Methods: Isolate was submitted to antimicrobial susceptibility testing including broth microdilution for polymyxin B.
Genomic and phenotypic characterisation of antimicrobial resistance in carbapenem-resistant Acinetobacter baumannii hyperendemic clones CC1, CC15, CC79 and CC25.
Int J Antimicrob Agents
December 2020
Article Synopsis
- The study investigates the spread of carbapenem-resistant Acinetobacter baumannii (CRAB) in Brazilian hospitals, focusing on specific clonal lineages.
- High rates of CRAB were identified, with predominant clonal complexes including CC1, CC15, CC79, and CC25, and a majority of the isolates exhibiting extensive drug resistance (XDR).
- The research highlights that specific resistance genes are prevalent in these clonal complexes, suggesting that their spread is influenced by antimicrobial resistance mechanisms under selective pressure in healthcare settings.
Detection of pandrug-resistant ST15 Acinetobacter baumannii causing bloodstream infection in an HSCT patient in Brazil.
J Antimicrob Chemother
September 2020