Publications by authors named "Carl Zhang"
Mineral particles have been widely used in bone tissue engineering scaffolds due to their osteoconductive and osteoinductive properties. Despite their benefits, mineral particles can induce undesirable inflammation and subsequent bone resorption. Aspirin (Asp) is an inexpensive and widely used anti-inflammatory drug.
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- Many patients with major depressive disorder do not benefit significantly from antidepressant treatment, but there's no clear definition of what "no meaningful benefit" (NMB) means.
- A study used equipercentile linking to determine that a 30% improvement in the 17-item Hamilton Depression Rating Scale (HDRS-17) score correlates with a Clinical Global Impressions-Improvement (CGI-I) score of 3, indicating minimal improvement, after 4 and 8 weeks of treatment with citalopram or escitalopram.
- The findings suggest that a maximum improvement of 30% in depression severity ratings can reliably indicate NMB from antidepressants for patients during short-term treatment periods.
The Clinical Global Impressions-Improvement (CGI-I) scale is widely used in clinical research to assess symptoms and functioning in the context of treatment. The correlates of the CGI-I with efficacy scales for adolescent major depressive disorder are poorly understood. This study focused on benchmarking CGI-I scores with changes in the Children's Depression Rating Scale-Revised (CDRS-R) and the Quick Inventory of Depressive Symptomatology-Adolescent (17-item) Self-Report (QIDS-A17-SR).
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