Tensile Force Limits of the Sheep Spine: Comparison to Forces Required to Extricate Grain Entrapped Victims.

Objectives: Grain storage facility entrapments continue to be of concern in the agricultural industry, with nearly 1,500 documented incidents recorded over the last 45 years. Previous research studies have shown that attempting to extricate a full-size pulling test dummy from a grain mass requires a substantial amount of tensile or pull force - e.g.

Capsule-Based dry powder inhaler evaluation using CFD-DEM simulations and next generation impactor data.

Capsule-based, single-dose dry powder inhalers (DPIs) are commonly-used devices to deliver medications to the lungs. This work evaluates the effect of the drug/excipient adhesive bonding and the DPI resistances on the aerosol performance using a combination of empirical multi-stage impactor data and a fully-coupled computational fluid dynamics (CFD) and discrete element method (DEM) model. Model-predicted quantities show that the primary modes of powder dispersion are a function of the device resistance.

Estimating Passive Stress Acting on a Grain Entrapment Victim's Chest.

Grain entrapments remain a major concern in the grain industry, with 1,100 incidents documented since the 1970s. One particular concern is the ability of a victim to breathe while entrapped in grain. Anecdotal reports suggest that victims struggle to breathe when entrapped in grain to a depth that covers their chests, yet some evidence indicates that victims should be able to breathe normally as long as their airways are not blocked regardless of depth.

Characteristics of multi-component formulation granules formed using distributive mixing elements in twin screw granulation.

This work examines the influence of pharmaceutical powder formulation characteristics on granule properties formed using distributive mixing elements (DMEs) in twin screw granulation. High and low drug dose formulations with three different active pharmaceutical ingredients (APIs) were considered. The type and concentration of the API in the formulation significantly affected the dry blend particle size distribution and the wet blend dynamic yield strength.

Angular circulation speed of tablets in a vibratory tablet coating pan.

In this work, a single tablet model and a discrete element method (DEM) computer simulation are developed to obtain the angular circulation speed of tablets in a vibratory tablet coating pan for range of vibration frequencies and amplitudes. The models identify three important dimensionless parameters that influence the speed of the tablets: the dimensionless amplitude ratio (a/R), the Froude number (aω2/g), and the tablet-wall friction coefficient, where a is the peak vibration amplitude at the drum center, ω is the vibration angular frequency, R is the drum radius, and g is the acceleration due to gravity. The models predict that the angular circulation speed of tablets increases with an increase in each of these parameters.

Investigation of the variability of NIR in-line monitoring of roller compaction process by using Fast Fourier Transform (FFT) analysis.

The purpose of this research was to investigate the variability of the roller compaction process while monitoring in-line with near-infrared (NIR) spectroscopy. In this paper, a pragmatic method in determining this variability of in-line NIR monitoring roller compaction process was developed and the variability limits were established. Fast Fourier Transform (FFT) analysis was used to study the source of the systematic fluctuations of the NIR spectra.

Stress results from two-dimensional granular shear flow simulations using various collision models.

Collision resolution is one of the key elements in a discrete element method algorithm for modeling granular flows. Several collision models have been proposed for this process. The hard-particle collision approach is typically used for dilute systems, or for those in which the assumption of binary and instantaneous particle-particle contact remains valid.