Publications by authors named "Carl Shannon"

Aims And Objectives: To describe the contextual, modal and psychological classification of medication errors in the emergency department to know the factors associated with the reported medication errors.

Background: The causes of medication errors are unique in every clinical setting; hence, error minimisation strategies are not always effective. For this reason, it is fundamental to understand the causes specific to the emergency department so that targeted strategies can be implemented.

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Iron homeostasis is a dynamic process that is tightly controlled to balance iron uptake, storage, and export. Reduction of dietary iron from the ferric to the ferrous form is required for uptake by solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 (Slc11a2) into the enterocytes. Both processes are proton dependent and have led to the suggestion of the importance of acidic gastric pH for the absorption of dietary iron.

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Article Synopsis
  • The study analyzes the genetic and phenotypic differences between two mouse inbred strains, C57BL/6J and C57BL/6N, which are widely used in genetic research.
  • Researchers performed comprehensive genome sequence comparisons, identifying coding variants and structural changes that differentiate the two strains, as well as significant phenotypic variations across multiple biological systems.
  • The findings suggest that the identified genetic differences could influence how mutations manifest in these strains, offering potential insights into underlying genetic mechanisms and candidate genes for further investigation.
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To maximize the sensitivity of detecting affects of genetic variants in mice, variables have been minimized through the use of inbred mouse lines, by eliminating infectious organisms and controlling environmental variables. However, the impact of standard animal husbandry and experimental procedures on the validity of experimental data is under appreciated. In this study we monitored the impact of these procedures by using parameters that reflect stress and physiological responses to it.

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