Publications by Carl Mg Vahldieck

Publications by authors named "Carl Mg Vahldieck"

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Short regulatory DNA sequences to target brain endothelial cells for gene therapy.

Hanna Graßhoff Helge Müller-Fielitz Godwin K Dogbevia Jakob Körbelin Jacqueline Bannach Carl Mg Vahldieck

J Cereb Blood Flow Metab

January 2022

Gene vectors targeting CNS endothelial cells allow to manipulate the blood-brain barrier and to correct genetic defects in the CNS. Because vectors based on the adeno-associated virus (AAV) have a limited capacity, it is essential that the DNA sequence controlling gene expression is short. In addition, it must be specific for endothelial cells to avoid off-target effects.

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