Publications by Carl Martin Nilsson

Publications by authors named "Carl Martin Nilsson"

Antimicrob Agents Chemother

June 2024

* A new compound called H6-335-P1 has been developed to disrupt bacterial biofilms by targeting the c-di-GMP signaling pathway, leading to the dispersal of bacteria into a more vulnerable planktonic state.
* Formulated as Disperazol, this water-soluble compound shows significantly enhanced efficacy when combined with the antibiotic ciprofloxacin in treating catheter-associated UTIs, demonstrating potential for improved treatment options.

- Carl Martin Nilsson's recent research focuses on improving treatment options for catheter-associated urinary tract infections (UTIs), specifically addressing issues related to biofilm formation by pathogenic bacteria.
- His latest article explores the combined use of the c-di-GMP modulating anti-biofilm compound Disperazol with ciprofloxacin, demonstrating its high efficacy in treating murine models of persistent UTIs.
- The study highlights the challenges posed by antibiotic resistance in standard treatments and emphasizes the need for innovative therapeutic strategies to reduce infection rates in hospitalized patients with urinary catheters.