Publications by authors named "Carl Gustav Saluste"
Bioorg Med Chem Lett
May 2012
Article Synopsis
- PI3K is a critical target for cancer therapies due to its role in various cancers, making its inhibition a viable treatment strategy.
- Researchers optimized imidazo [1,2-a] pyrazines, leading to the discovery of compound 14 (ETP-46321), known for its strong activity and favorable pharmacokinetics when taken orally.
- In studies, ETP-46321 effectively reduced AKT(Ser473) phosphorylation in a time-dependent manner, correlating with its presence in tumor tissues and demonstrating significant tumor growth inhibition in a mouse model with a K-Ras mutation.
