Publications by authors named "Carl Chmelik"
Ciliates, such as evolved complex mechanisms to determine both the location and dimensions of cortical organelles such as the oral apparatus (OA: involved in phagocytosis), cytoproct (Cyp: for eliminating wastes), and contractile vacuole pores (CVPs: involved in water expulsion). Mutations have been recovered in that affect both the localization of such organelles along anterior-posterior and circumferential body axes and their dimensions. Here we describe , a ciliate pattern gene that encodes a conserved Beige-BEACH domain-containing protein a with possible protein kinase A (PKA)-anchoring activity.
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- During sexual reproduction in ciliates like Tetrahymena thermophila, specialized adhesion zones are formed to allow for the exchange of gametic pronuclei through a membrane called the mating junction.
- The passage of pronuclei through this junction requires microtubules and results in two membrane breaches that need to be sealed post-fertilization.
- Rather than simply growing new membrane from the edges like in other cells, the breaches transform into complex membrane structures that grow into the partner's cytoplasm and connect to the plasma membrane, revealing a unique mechanism for membrane restoration.