Publications by authors named "Carita Sequeira"
Article Synopsis
- Bacterial nonulosonic acids, like pseudaminic acids, are 9-carbon monosaccharides that have structural differences at five stereogenic centers, making them potential candidates for vaccines against drug-resistant infections.
- The unique stereochemistry of these acids has drawn significant interest from chemists due to their complex structures.
- This study presents an improved synthesis method for 2,4-di-acetyl-l-altrose, a crucial hexose in producing pseudaminic acids, by using l-fucose and addressing issues found in earlier synthesis attempts.
Short-chain fatty acids (SCFAs) are produced by anaerobic gut microbiota in the large bowel. Qualitative and quantitative measurements of SCFAs in the intestinal tract and the fecal samples are important to understand the complex interplay between diet, gut microbiota and host metabolism homeostasis. To develop a new LC-MS/MS method for sensitive and reliable analysis of SCFAs in human fecal samples, 3-nitrophenylhydrazine (3NPH) was employed for pre-analytical derivatization to convert ten C2-C6 SCFAs to their 3-nitrophenylhydrazones under a single set of optimized reaction conditions and without the need of reaction quenching.
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