Publications by authors named "Carissa F Klanseck"
Proc Natl Acad Sci U S A
October 2020
Article Synopsis
- - The inner ear is crucial for hearing and balance, with the tip-link protein complex playing a key role in sensing tiny mechanical stimuli by opening transduction channels for sensory perception.
- - Protocadherin-15 and cadherin-23 are large proteins involved in forming the tip-link, which is linked to hearing and balance disorders; their structure was examined using X-ray crystallography.
- - Advanced molecular dynamics simulations helped model the structural properties of protocadherin-15, offering insights into how it may function as a flexible or rigid component in inner-ear sensory perception and its relevance to related diseases.
