Publications by authors named "Carissa A Huynh"
Article Synopsis
- * In a study of 982 cancer patients from 2020 to 2023, most received the initial vaccine and one booster, but the uptake for the newer bivalent booster was significantly low at only 30.1%.
- * Despite low booster rates, nearly all participants showed improved immune responses after receiving at least two boosters, and those who got boosted had a lower risk of mortality, highlighting the need for better strategies to encourage vaccinations among this vulnerable group.
The global scientific response to COVID 19 highlighted the urgent need for increased throughput and capacity in bioanalytical laboratories, especially for the precise quantification of proteins that pertain to health and disease. Acoustic ejection mass spectrometry (AEMS) represents a much-needed paradigm shift for ultra-fast biomarker screening. Here, a quantitative AEMS assays is presented, employing peptide immunocapture to enrich (i) 10 acute phase response (APR) protein markers from plasma, and (ii) SARS-CoV-2 NCAP peptides from nasopharyngeal swabs.
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- - Patients with cancer have a higher risk of severe outcomes from COVID-19 and show weakened immune responses to vaccines, highlighting the importance of regular boosters in this group
- - A study of 982 cancer patients found high initiation of vaccination (92.3% received the primary vaccine) but lower uptake of boosters, especially among younger patients and racial minorities
- - Receiving multiple booster shots significantly increased antibody levels and T-cell responses, leading to a lower risk of death, indicating the need for improved strategies to boost vaccination rates among high-risk cancer patients
The epithelium lining airspaces of the human lung is maintained by regional stem cells, including basal cells of pseudostratified airways and alveolar type 2 (AT2) pneumocytes of the gas-exchange region. Despite effective techniques for long-term preservation of airway basal cells, procedures for efficient preservation of functional epithelial cell types of the distal gas-exchange region are lacking. Here we detail a method for cryobanking of epithelial cells from either mouse or human lung tissue for preservation of their phenotypic and functional characteristics.
View Article and Find Full Text PDFLongitudinal studies of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine-induced immune responses in patients with cancer are needed to optimize clinical care. In a prospective cohort study of 366 (291 vaccinated) patients, we measured antibody levels [anti-spike (IgG-(S-RBD) and anti-nucleocapsid immunoglobulin] at three time points. Antibody level trajectories and frequency of breakthrough infections were evaluated by tumor type and timing of treatment relative to vaccination.
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