Publications by authors named "Carine Visee"
Perianal fistulas in Crohn's disease are frequent and disabling, with a major impact on patients' quality of life. Cell-based therapy using mesenchymal stem cells represents new hope for these patients, but long-term efficacy remains challenging. In a pilot study, including patients with refractory complex perianal fistulas, autologous adipose-derived stromal vascular fraction (ADSVF) combined with microfat achieved combined remission in 60% of cases, with a good safety profile at 1 year.
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- Mesenchymal stem cell therapy shows promise for treating perianal Crohn's fistulas that do not respond to conventional treatments, which are challenging and debilitating.
- A documented case involved a patient who received autologous adipose-derived stromal vascular fraction (ADSVF) and microfat injections, leading to remarkable healing of the fistulas within 12 weeks and sustained improvement at 48 weeks.
- The successful outcome suggests that combining ADSVF and microfat may provide a new effective treatment approach for patients suffering from these complex fistulas associated with Crohn's disease.