A Ratiometric Fluorescent Probe for Cisplatin: Investigating the Intracellular Reduction of Platinum(IV) Prodrug Complexes.

The Pt prodrug strategy has emerged as an excellent alternative to tackle the problems associated with conventional Pt drug therapy. However, there is a lack of tools to study how this new class of Pt drugs are processed at the cellular level. Herein, we report the first ratiometric probe for cisplatin detection and use it to investigate Pt anticancer complexes in biological systems.