Publications by authors named "Carine Merklen"
Aliment Pharmacol Ther
April 2023
Article Synopsis
- This study focuses on the severe side effects of BRAF and MEK inhibitors, specifically colitis, in patients with metastatic melanoma, as it's a standard treatment for V600E/K BRAF mutant cases.
- Researchers analyzed 10 patients hospitalized for colitis after using these drugs, noting common symptoms like diarrhea and abdominal pain, along with severe medical complications, including ulcerations in the right colon.
- The findings indicate that these medications can lead to serious gastrointestinal issues, with a significant number of patients having to discontinue treatment or requiring surgery, highlighting the need for careful monitoring.
