NF-κB activation and severity of gastritis in Helicobacter pylori-infected children and adults.

Background: In contrast to adults, Helicobacter pylori gastritis in children is reported as milder and ulcer disease as uncommon, but unequivocal data are lacking.

Objectives: To compare the frequency of gastro-duodenal ulcers in children and adults as well as the proportion of Helicobacter pylori infection in these patients and to study the effect of chronological age on NF-κB activation and on severity of gastritis.

Design: Patients referred in one pediatric and one adult facility for upper GI endoscopy were included.