Publications by authors named "Carine Coffre"
Article Synopsis
- A phase 3 clinical trial investigated if intravenous hydrocortisone could reduce mortality in patients with severe community-acquired pneumonia compared to a placebo.
- The study involved 800 patients, and results showed that those receiving hydrocortisone had a significantly lower death rate (6.2%) at 28 days versus 11.9% in the placebo group.
- Additionally, patients on hydrocortisone required less mechanical ventilation and vasopressors compared to those on placebo, with similar rates of hospital-acquired infections and bleeding risks.
Importance: Coronavirus disease 2019 (COVID-19) is associated with severe lung damage. Corticosteroids are a possible therapeutic option.
Objective: To determine the effect of hydrocortisone on treatment failure on day 21 in critically ill patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and acute respiratory failure.
Context: Clinical studies involve an increasing amount of data collection and management. However, there is no specific quality standard sufficiently practical, in free access, and open for data management and the underlying IT-infrastructure in academic units. European Clinical Research Infrastructures Network (ECRIN) published standard requirements for certified data management units.
View Article and Find Full Text PDFThere is no standard method for the diagnosis of prosthetic joint infection (PJI). The contribution of 16S rRNA gene PCR sequencing on a routine basis remains to be defined. We performed a prospective multicenter study to assess the contributions of 16S rRNA gene assays in PJI diagnosis.
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