Publications by authors named "Carina Schreiner"
Cellular senescence of normal human cells has by now far exceeded its initial role as a model system for aging research. Many reports show the accumulation of senescent cells in vivo, their effect on their microenvironment and its double-edged role as tumour suppressor and promoter. Importantly, removal of senescent cells delays the onset of age-associated diseases in mouse model systems.
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- Aging is a complex process involving body function decline due to random damage, but it has genetic repair mechanisms that may help mitigate these effects.
- Recent research has focused on miRNAs, small molecules that can regulate the expression of numerous genes and are believed to play a role in physiological processes, including aging.
- The study identified four specific miRNAs that are consistently down-regulated in various aging cell models, linking their decrease to higher levels of certain target genes associated with aging, particularly the cdk inhibitor p21/CDKN1A.