Publications by authors named "Carina P Doyle"
Article Synopsis
- Vocal fold fibrosis significantly impacts voice quality and life satisfaction, and current treatments are not very effective due to issues like scarring and further damage.
- The study focused on the role of YAP/TAZ proteins in response to vocal fold injury and their interaction with the TGF-β/SMAD signaling pathway, which is crucial in fibrosis development.
- Findings suggest that targeting YAP/TAZ might be a promising new approach for treating vocal fold fibrosis, as their activation influences fibroblast behavior and the fibrosis process.
Fibrosis of the vocal folds poses a substantive clinical challenge potentially underlying the rapid proliferation of direct steroid injections into the upper airway. The variable clinical response to glucocorticoids (GCs) in the vocal folds is likely related to diversity inherent to GCs and patient-specific, and upstream, cell-specific responses to GCs. Broadly, we hypothesize the disparity in clinical outcomes are due to undesirable effects of GCs on resident fibroblasts.
View Article and Find Full Text PDF