Validity and reliability of self-reported and neural measures of listening effort.

Listening effort can be defined as a measure of cognitive resources used by listeners to perform a listening task. Various methods have been proposed to measure this effort, yet their reliability remains unestablished, a crucial step before their application in research or clinical settings. This study encompassed 32 participants undertaking speech-in-noise tasks across two sessions, approximately a week apart.

Phase-locking of Neural Activity to the Envelope of Speech in the Delta Frequency Band Reflects Differences between Word Lists and Sentences.

The envelope of a speech signal is tracked by neural activity in the cerebral cortex. The cortical tracking occurs mainly in two frequency bands, theta (4-8 Hz) and delta (1-4 Hz). Tracking in the faster theta band has been mostly associated with lower-level acoustic processing, such as the parsing of syllables, whereas the slower tracking in the delta band relates to higher-level linguistic information of words and word sequences.

Decreased Resting-State Alpha Self-Synchronization in Depressive Disorder.

. Depression disorder has been associated with altered oscillatory brain activity. The common methods to quantify oscillatory activity are Fourier and wavelet transforms.

Alpha Oscillations During Effortful Continuous Speech: From Scalp EEG to Ear-EEG.

Objective: The purpose of this study was to investigate alpha power as an objective measure of effortful listening in continuous speech with scalp and ear-EEG.

Methods: Scalp and ear-EEG were recorded simultaneously during presentation of a 33-s news clip in the presence of 16-talker babble noise. Four different signal-to-noise ratios (SNRs) were used to manipulate task demand.

Speech to noise ratio improvement induces nonlinear parietal phase synchrony in hearing aid users.

Objectives: Comprehension of speech in adverse listening conditions is challenging for hearing-impaired (HI) individuals. Noise reduction (NR) schemes in hearing aids (HAs) have demonstrated the capability to help HI to overcome these challenges. The objective of this study was to investigate the effect of NR processing (inactive, where the NR feature was switched off, vs.

EEG Phase Synchrony Reflects SNR Levels During Continuous Speech-in-Noise Tasks.

Comprehension of speech in noise is a challenge for hearing-impaired (HI) individuals. Electroencephalography (EEG) provides a tool to investigate the effect of different levels of signal-to-noise ratio (SNR) of the speech. Most studies with EEG have focused on spectral power in well-defined frequency bands such as alpha band.

Hearing Aid Noise Reduction Lowers the Sustained Listening Effort During Continuous Speech in Noise-A Combined Pupillometry and EEG Study.

Objectives: The investigation of auditory cognitive processes recently moved from strictly controlled, trial-based paradigms toward the presentation of continuous speech. This also allows the investigation of listening effort on larger time scales (i.e.

Effects of Hearing Aid Noise Reduction on Early and Late Cortical Representations of Competing Talkers in Noise.

Objectives: Previous research using non-invasive (magnetoencephalography, MEG) and invasive (electrocorticography, ECoG) neural recordings has demonstrated the progressive and hierarchical representation and processing of complex multi-talker auditory scenes in the auditory cortex. Early responses (<85 ms) in primary-like areas appear to represent the individual talkers with almost equal fidelity and are independent of attention in normal-hearing (NH) listeners. However, late responses (>85 ms) in higher-order non-primary areas selectively represent the attended talker with significantly higher fidelity than unattended talkers in NH and hearing-impaired (HI) listeners.

Estimating Conditional Transfer Entropy in Time Series Using Mutual Information and Nonlinear Prediction.

We propose a new estimator to measure directed dependencies in time series. The dimensionality of data is first reduced using a new non-uniform embedding technique, where the variables are ranked according to a weighted sum of the amount of new information and improvement of the prediction accuracy provided by the variables. Then, using a greedy approach, the most informative subsets are selected in an iterative way.

Three New Outcome Measures That Tap Into Cognitive Processes Required for Real-Life Communication.

To increase the ecological validity of outcomes from laboratory evaluations of hearing and hearing devices, it is desirable to introduce more realistic outcome measures in the laboratory. This article presents and discusses three outcome measures that have been designed to go beyond traditional speech-in-noise measures to better reflect realistic everyday challenges. The outcome measures reviewed are: the Sentence-final Word Identification and Recall (SWIR) test that measures working memory performance while listening to speech in noise at ceiling performance; a neural tracking method that produces a quantitative measure of selective speech attention in noise; and pupillometry that measures changes in pupil dilation to assess listening effort while listening to speech in noise.

Neural Representation Enhanced for Speech and Reduced for Background Noise With a Hearing Aid Noise Reduction Scheme During a Selective Attention Task.

Objectives: Selectively attending to a target talker while ignoring multiple interferers (competing talkers and background noise) is more difficult for hearing-impaired (HI) individuals compared to normal-hearing (NH) listeners. Such tasks also become more difficult as background noise levels increase. To overcome these difficulties, hearing aids (HAs) offer noise reduction (NR) schemes.

An exploratory Study of EEG Alpha Oscillation and Pupil Dilation in Hearing-Aid Users During Effortful listening to Continuous Speech.

Individuals with hearing loss allocate cognitive resources to comprehend noisy speech in everyday life scenarios. Such a scenario could be when they are exposed to ongoing speech and need to sustain their attention for a rather long period of time, which requires listening effort. Two well-established physiological methods that have been found to be sensitive to identify changes in listening effort are pupillometry and electroencephalography (EEG).

Absolute Eye Gaze Estimation With Biosensors in Hearing Aids.

People with hearing impairment typically have difficulties following conversations in multi-talker situations. Previous studies have shown that utilizing eye gaze to steer audio through beamformers could be a solution for those situations. Recent studies have shown that in-ear electrodes that capture electrooculography in the ear (EarEOG) can estimate the eye-gaze relative to the head, when the head was fixed.

Neuroimaging of the human visceral pain system-A methodological review.

During the last decades there has been a tremendous development of non-invasive methods for assessment of brain activity following visceral pain. Improved methods for neurophysiological and brain imaging techniques have vastly increased our understanding of the central processing of gastrointestinal sensation and pain in both healthy volunteers as well as in patients suffering from gastrointestinal disorders. The techniques used are functional magnetic resonance imaging (fMRI), positron emission tomography (PET), electroencephalography (EEG)/evoked brain potentials (EPs), magnetoencephalography (MEG), single photon emission computed tomography (SPECT), and the multimodal combinations of these techniques.

Single-channel in-ear-EEG detects the focus of auditory attention to concurrent tone streams and mixed speech.

Objective: Conventional, multi-channel scalp electroencephalography (EEG) allows the identification of the attended speaker in concurrent-listening ('cocktail party') scenarios. This implies that EEG might provide valuable information to complement hearing aids with some form of EEG and to install a level of neuro-feedback.

Approach: To investigate whether a listener's attentional focus can be detected from single-channel hearing-aid-compatible EEG configurations, we recorded EEG from three electrodes inside the ear canal ('in-Ear-EEG') and additionally from 64 electrodes on the scalp.

Acute dosing of vortioxetine strengthens event-related brain activity associated with engagement of attention and cognitive functioning in rats.

Studies of the antidepressant vortioxetine have demonstrated beneficial effects on cognitive dysfunction associated with depression. To elucidate how vortioxetine modulates neuronal activity during cognitive processing we investigated the effects of vortioxetine (3 and 10mg/kg) in rats performing an auditory oddball (deviant target) task. We investigated neuronal activity in target vs non-target tone responses in vehicle-treated animals using electroencephalographic (EEG) recordings.

Adapted wavelet transform improves time-frequency representations: a study of auditory elicited P300-like event-related potentials in rats.

Objective: Active auditory oddball paradigms are simple tone discrimination tasks used to study the P300 deflection of event-related potentials (ERPs). These ERPs may be quantified by time-frequency analysis. As auditory stimuli cause early high frequency and late low frequency ERP oscillations, the continuous wavelet transform (CWT) is often chosen for decomposition due to its multi-resolution properties.

Acupuncture for Pain in Chronic Pancreatitis: A Single-Blinded Randomized Crossover Trial.

Objectives: Many patients with painful chronic pancreatitis (CP) have insufficient effect of treatment, and the prevalence of adverse effects is high. Consequently, alternatives to conventional management are needed. We aimed to study the effect of acupuncture in painful CP.

Integrity of central nervous function in diabetes mellitus assessed by resting state EEG frequency analysis and source localization.

Diabetes mellitus (DM) is associated with structural and functional changes of the central nervous system. We used electroencephalography (EEG) to assess resting state cortical activity and explored associations to relevant clinical features. Multichannel resting state EEG was recorded in 27 healthy controls and 24 patients with longstanding DM and signs of autonomic dysfunction.

Is Timing of Medical Therapy Related to Outcome in Painful Chronic Pancreatitis?

Objectives: The authors investigated if timing of medical treatment is associated with the analgesic effect of pregabalin or placebo in patients with chronic pancreatitis (CP).

Methods: Sixty-four patients received pregabalin (150-300 mg twice a day) or matching placebo for 3 consecutive weeks. Responders to treatment were defined as patients with a reduction in clinical pain scores of 30% or greater.

Stochastic Pharmacokinetic-Pharmacodynamic Analysis of the Effect of Transdermal Buprenorphine on Electroencephalogram and Analgesia.

Background: The analgesic effect of opioids is often based on subjective one dimensional measurements. Electroencephalography (EEG) offers a possibility to objectively quantify the brain's activity before and after the administration of opioids. The aim of this study was to investigate the pharmacokinetic-pharmacodynamic (PKPD) properties of the buprenorphine transdermal patch on resting EEG and pain tolerance.

Multivariate analysis of single-sweep evoked brain potentials for pharmaco-electroencephalography.

Background And Aims: Current findings on altered evoked potentials (EPs) caused by morphine are based on common alterations for a group of subjects after drug administration. However, this ignores the analysis of individual responses, which may explain the clinical differences in efficacy. Therefore, we explored the individual responses to morphine in terms of the altered single-sweep characteristics in a placebo-controlled crossover study.

A New Method for Sham-Controlled Acupuncture in Experimental Visceral Pain - a Randomized, Single-Blinded Study.

Objective: Acupuncture is increasingly used as an alternative to medical therapy for various pain conditions. To study the effect of acupuncture in experimental and clinical studies, a control condition with sham acupuncture is needed. However, as such models have not been established in assessment of acupunctures effect against visceral pain, this study aimed to validate a new method for blinded sham acupuncture in experimental rectal pain.