Immunosuppression in canine renal allografts using niridazole.

The immunosuppressive activity of niridazole in unmatched kidney allografts in nephrectomized dogs was studied. The drug alone was not effective, but improved survival when used with azathioprine and prednisolone or azathioprine alone. However, niridazole was toxic in dogs in the doses used (25 or 50 mg/kg/day).

Renal impairment and its reversibility following variable periods of complete ureteric obstruction.

There is debate concerning the time course and degree of recovery possible after relief of complete unilateral ureteric obstruction. This study in dogs investigates these features. One ureter was occluded for varying periods, and then reimplanted into the bladder.

The combined use of antilymphocytic serum and bone marrow infusion in immunological suppression.

The combined use of antilymphocytic serum and live donor-specific bone marrow cells has produced significant immunosuppression in dogs as judged by renal allograft survival. This combined action is specific in that it cannot be reprodued whether given alone or when live donor-specific bone marrow cells are replaced by dead donor-specific bone marrow cells or other antigens. The study has paved the way for human trials.

The role of bradykinin in endotoxic shock of intestinal origin.

A relationship was looked for between blood levels of bradykinin and endotoxaemia produced by superior mesenteric artery occlusion in the rabbit. The levels of bradykinin were unrelated to and unaltered by the degree of endotoxaemia observed in the systemic and portal circulations. These findings suggest that bradykinin is not responsible for the release of endotoxin from the gut, or the circulatory collapse which follows.