Fractional CO2 laser and adjunctive therapies in skin of color melasma patients.

Background: Ablative lasers have long been considered an unfavorable option for melasma in patients with skin of color and continue to be underutilized.

Objective: To evaluate the safety and outcomes of ablative fractional CO lasers on refractory melasma in patients with skin of color.

Methods: A retrospective chart review of 12 patients from a single-center dermatology clinic.

Treatment of Imiquimod Resistant Epidermodysplasia Verruciformis With Ingenol Mebutate.

Background: Epidermodysplasia verruciformis (EV) is a rare genetic disorder characterized by widespread human papillomavirus (HPV) associated lesions and an increase susceptibility to cutaneous malignancies. A host of medications traditionally used to treat warty lesions have been used with variable results and limited success. To our knowledge, we describe the first reported case of a patient with Imiquimod resistant EV successfully treated with topical ingenol mebutate (Picato).

A visual screen of protein localization during sporulation identifies new components of prospore membrane-associated complexes in budding yeast.

During ascospore formation in Saccharomyces cerevisiae, the secretory pathway is reorganized to create new intracellular compartments, termed prospore membranes. Prospore membranes engulf the nuclei produced by the meiotic divisions, giving rise to individual spores. The shape and growth of prospore membranes are constrained by cytoskeletal structures, such as septin proteins, that associate with the membranes.

A highly redundant gene network controls assembly of the outer spore wall in S. cerevisiae.

The spore wall of Saccharomyces cerevisiae is a multilaminar extracellular structure that is formed de novo in the course of sporulation. The outer layers of the spore wall provide spores with resistance to a wide variety of environmental stresses. The major components of the outer spore wall are the polysaccharide chitosan and a polymer formed from the di-amino acid dityrosine.

Use of a nanocrystalline silver dressing and vacuum-assisted closure in a severely burned dog.

Objective: To describe the first veterinary use of a nanocrystalline silver dressing (NSD) and use of vacuum-assisted closure (VAC) to treat a severely burned dog.

Case Or Series Summary: A 1-year-old female intact American Staffordshire Terrier with 50% total body surface area burned was referred for definitive care approximately 18-24 hours post injury. The dog was treated with crystalloid fluids, hydroxyethyl starch, and antimicrobials based on culture and sensitivity results of wound cultures, fresh frozen plasma, human serum albumin, and packed red cells.