Leukocyte arylsulfatase A activity in patients with alcohol-related cirrhosis.

Arylsulfatase (ASA) enzyme deficiency is associated with metachromatic leukodystrophy (MLD), which is a hereditary myelin metabolic disease. It has been proposed that in alcoholic subjects with abnormal ASA, the accumulation of sulfatides may lead to demyelinization and generalized cerebral atrophy. ASA may be diminished in subjects with alcoholic cirrhosis having encephalopathic manifestations.

Arylsulfatase A levels in patients with chronic alcoholism.

Background: The goal of this study was to find the association between low arylsulfatase A (ASA) activity and psychiatric disorders in chronic alcoholic patients.

Methods: The study was carried out in 30 chronic alcoholic patients (27 male, 3 female); age range was 25-65 years. There were 20 normal controls (18 males, 2 females), and age range was 24-67 years.

Penicillamine produces changes in the acute blood elimination and tissue accumulation of thallium.

D-penicillamine (PCA) is used by some physicians in human thallium intoxication. With the aim of learning how the blood thallium altered kinetics and the modifications produced on the tissue accumulation, we administered PCA to white male thallium dosed rabbits. The method consisted of intravenous (i.

[Acute effects of the administration of potassium on the organ uptake of Tl+ in the rabbit].

This paper describes the acute effects produced by administering potassium (2.7 and 5.5 mg.

[Acute pharmacokinetics of the Tl+ ion in the rabbit. 3-compartment model].

New Zealand rabbits were used to determine the acute kinetics of the Tl+ ion (0 to 90 minutes) following intravenous administration of two doses of Tl+ (10 mg.kg-1 and 30 mg.kg-1).

The distribution of thallous ion between blood cells and plasma at equilibrium.

We have investigated the distribution of thallous ions between plasma and blood cells in whole blood both in vitro and in vivo (rabbit whole blood) and in vitro (human whole blood). The means of the percentual distribution are within the range of 61.4 to 64.