Recurrence rate and quality of life in women with borderline ovarian tumours, according to surgical approach.

Objectives: To assess the recurrence rate and quality of life (QOL) in women with a history of borderline ovarian tumours (BOTs) based on the type of surgery (conservative vs non-conservative) in Spain.

Study Design: A retrospective analysis was conducted of 85 women treated for BOTs between 2007 and 2023 at two hospitals. QOL questionnaires were administered face-to-face to eligible patients.

Clinical Outcomes With Immune Checkpoint Inhibitors in Patients With FGFR2/3, MTAP or ERBB2 Genomic Alterations in Advanced Urothelial Carcinoma.

Background: FGFR2/3, MTAP and ERBB2 genomic alterations have treatment targets in advanced urothelial carcinoma (aUC). These alterations may affect tumor microenvironment and outcomes with immune checkpoint inhibitors (ICIs) in aUC.

Patients And Methods: We identified patients with available genomic data in our multi-institution cohort of patients with aUC treated with ICI.

Response and Outcomes of Maintenance Avelumab After Platinum-Based Chemotherapy (PBC) in Patients With Advanced Urothelial Carcinoma (aUC): "Real World" Experience.

Background: Platinum-based chemotherapy (PBC) followed by avelumab switch maintenance in nonprogressors is standard first line (1L) treatment for advanced urothelial carcinoma (aUC). We describe clinical features and outcomes in a "real-world' cohort treated with avelumab maintenance for aUC.

Materials And Methods: This was a retrospective cohort study of patients (pts) who received 1L switch maintenance avelumab after no progression on PBC for aUC.

Pupillometric evidence for a temporal expectations-based account of persistence under temporal uncertainty.

People often quit waiting for delayed rewards when the exact timing of those rewards is uncertain. This behavior often has been attributed to self-control failure. Another possibility is that quitting is the result of a rational decision-making process in the face of uncertainty, based on the decision-maker's expectations about the possible arrival times of the awaited reward.

Multiband effects on the upper critical field angular dependence of 122-family iron pnictide superconductors.

Detailed measurements of the in-plane resistivity were performed in a high-quality Ba([Formula: see text])[Formula: see text] ([Formula: see text]) single crystal, in magnetic fields up to 9 T and with different orientations [Formula: see text] relative to the crystal c axis. A significant [Formula: see text] rounding is observed just above the superconducting critical temperature [Formula: see text] due to Cooper pairs created by superconducting fluctuations. These data are analyzed in terms of a generalization of the Aslamazov-Larkin approach, that extends its applicability to high reduced-temperatures and magnetic fields.

The cotton-strip assay as an environmental surveillance tool for ecological integrity assessment of rivers affected by WWTP effluents.

Environmental impact studies of rivers affected by wastewater treatment plant (WWTP) effluents have been greatly restricted by the difficulties associated with carrying out bioassays in the field and also by the complex interactions between the pollutants contained in the discharges. The cotton-strip assay (CSA) enables study of the organic matter decomposition potential, an important ecosystem process in rivers, by taking all of the factors affecting this process into account. However, the CSA has never been used for assessment of WWTP effluents.

Biomonitoring freshwater FISH farms by measuring nitrogen concentrations and the δN signal in living and devitalized moss transplants.

The trophic balance of freshwater aquaculture activities has traditionally been monitored by chemical analysis of water; however, the parameters measured are usually characterized by high temporal variability. Aquatic mosses can be used as biomonitors as they integrate both continuous and episodic contamination events. Here we report, for the first time, a method for monitoring N enrichment in the surroundings of fish farms by measuring the N content and isotopic signal (δN) of transplanted living and devitalized specimens of the aquatic moss Fontinalis antipyretica.

Assessing changes in the toxicity of effluents from intensive marine fish farms over time by using a battery of bioassays.

Although intensive marine fish farming is often assumed to be eco-friendly, the associated activity can lead to chronic exposure of marine organisms to potentially toxic discharges. Moreover, despite the increasing popularity of integrated multi-trophic aquaculture (IMTA), studies of the effects of fish farm effluents are almost non-existent. In the present study, the changes in the toxic potential of effluents from five land-based marine fish farms in NW Spain subjected for different lengths of time to a biodegradation procedure (for 0, 48, 120, and 240 h) were assessed in a battery of bioassays including organisms from different trophic levels (Vibrio fischeri, Isochrysis galbana, and Paracentrotus lividus).

Differences in Metal Accumulation in the Growing Shoot Tips and Remaining Shoot Tissue in Three Species of Brown Seaweeds.

In this study we compared the accumulation of eight metals and two metalloids in the growing tips and the remaining shoot tissue of three species of brown seaweeds commonly used in biomonitoring studies (Fucus ceranoides, Fucus spiralis and Ascophyllum nodosum). Regression analysis of the data obtained showed that there was no statistically significant difference in accumulation in numerous cases; although most of the relationships were significant, many of the coefficients of determination were low. However, the concentrations of Mn and Zn in the growing tips were closely related to the concentrations in the rest of the tissue in all three species, possibly due to redistribution of these elements.

Interannual changes in δ¹⁵N values in Fucus vesiculosus L.

The natural abundance of (15)N (δ(15)N) has been widely used to detect anthropogenically derived N loads in environmental impact studies. The present study involved retrospective analysis of subsamples of Fucus vesiculosus L. collected during a period of three years (2008-2010) from two sites: a control site, within a coastal reference area, and an area affected by the effluents of a marine land-based fish farm.

A meta-analysis approach to the effects of fish farming on soft bottom polychaeta assemblages in temperate regions.

Marine fish farms could cause environmental disturbances on the sediment due to uneaten food and fish faeces that impact the marine benthos. Polychaete assemblages are considered good indicators of environmental perturbations. The present study aimed to establish groups of polychaetes as potential indicators of fish farm pollution.

Assessing the toxicity of chemical compounds associated with land-based marine fish farms: the sea urchin embryo bioassay with Paracentrotus lividus and Arbacia lixula.

In aquaculture, disinfection of facilities, prevention of fish diseases, and stimulation of fish growth are priority goals and the most important sources of toxic substances to the environment, together with excretory products from fish. In the present study, embryos of two species of sea urchin (Paracentrotus lividus and Arbacia lixula) were exposed to serial dilutions of six antibiotics (amoxicillin (AMOX), ampicillin, flumequine (FLU), oxytetracycline (OTC), streptomycin (ST), and sulfadiazine [SFD]) and two disinfectants (sodium hypochlorite (NaClO) and formaldehyde [CH(2)O]). Alterations in larval development were studied, and the effective concentrations (ECs) were calculated to evaluate the toxicity of the substances.

Designing an integrated environmental monitoring plan for land-based marine fish farms located at exposed and hard bottom coastal areas.

The increase in aquaculture activities in the last few decades has not been accompanied by a corresponding increase in environmental controls and regulations. In this context, the application of environmental monitoring plans (EMPs) has become necessary to assess the environmental impact associated with fish farming wastes. The objective of this review paper is to evaluate the suitability of experimental and analytical procedures as monitoring tools for inclusion in EMPs for intensive land-based marine fish farms (LBMFFs).

Identification of specific malformations of sea urchin larvae for toxicity assessment: application to marine pisciculture effluents.

Standard toxicity screening tests are useful tools in the management of impacted coastal ecosystems. To our knowledge, this is the first time that the sea urchin embryo development test has been used to evaluate the potential impact of effluents from land-based aquaculture farms in coastal areas. The toxicity of effluents from 8 land-based turbot farms was determined by calculating the percentage of abnormal larvae, according to two criteria: (a) standard, considering as normal pyramid-shaped larvae with differentiated components, and (b) skeletal, a new criterion that considers detailed skeletal characteristics.

Implementation of a minimal set of biological tests to assess the ecotoxic effects of effluents from land-based marine fish farms.

Environmental monitoring plans (EMP) that include chemical analysis of water, a battery of bioassays and the study of local hydrodynamic conditions are required for land-based marine aquaculture. In this study, the following standardized toxicity tests were performed to assess the toxicity of effluents from eight land-base marine fish farms (LBMFFs) located on the northwest coast of Spain: bacterial bioluminescence (with Vibrio fischeri at 15 and 30 min), microalgal growth (with Phaeodactyllum tricornutum and Isochrysis galbana) and sea urchin larval development (with Paracentrotus lividus and Arbacia lixula). These bioassays were evaluated for inclusion in routine fish farm monitoring.

Linking δ 15N and histopathological effects in molluscs exposed in situ to effluents from land-based marine fish farms.

Histopathological alterations can indicate time-integrated impacts on organisms stemming from alterations at lower biological organisation levels. Long-term (native mussels) and short-term (transplanted clams) changes in the tissues of molluscs exposed to the effluents from two land-based marine fish farms (LBMFFs) were determined. Histological alterations were related to the δ(15)N isotopic signal measured in mussels and macroalgae.

Influence of salinity on fertilization and larval development toxicity tests with two species of sea urchin.

Sea urchin embryo-larval development (ELD) and fertilization tests have been widely used in ecotoxicity studies and are included in regulatory frameworks. Biological processes occur naturally within a range of salinity that depends on the species considered. In an attempt to determine the optimum range of salinity, ELD and fertilization bioassays were performed at different salinities (15-40.

Multiquanta vortex entry and vortex-antivortex pattern expansion in a superconducting microsquare with a magnetic dot.

We investigate the nucleation of superconductivity in a microsquare with a magnetic dot on top. The cusplike behavior of the calculated normal-superconducting phase boundaries, T(c)(H), shows a transition between short-period to long-period oscillations when going from positive to negative applied fields, H. Vorticity changes by more than 1, indicating multiquanta vortex entries, have been detected along this asymmetric T(c)(H) boundary.

Fluctuation induced diamagnetism in the zero magnetic field limit in a low temperature superconducting alloy.

By using a Pb-18 at. % In alloy, the fluctuation induced diamagnetism was measured in the zero magnetic field limit, never observed until now in a low-T(C) superconductor. This allows us to disentangle the dynamic and the nonlocal electrodynamic effects from the short-wavelength fluctuation effects.

First observation for a cuprate superconductor of fluctuation-induced diamagnetism well inside the finite-magnetic-field regime.

For the first time for a cuprate superconductor, measurements performed above T(c) in high quality grain aligned La1.9Sr0.1CuO4 samples have allowed the observation of the thermal fluctuation induced diamagnetism well inside the finite-magnetic-field fluctuation regime.