Long-term effectiveness and safety of XEN45 in open-angle glaucoma patients.

Background: To investigate the long-term effectiveness and safety of XEN45 implant, either alone or in combination with phacoemulsification, in eyes with open-angle glaucoma (OAG).

Methods: Retrospective and single center study conducted on consecutive OAG patients who underwent a XEN45 implant between February-2017 and December-2021. The primary endpoint was the mean intraocular pressure (IOP) lowering from preoperative values.

Effectiveness and Safety of Xen Gel Stent in Glaucoma Surgery: A Systematic Review of the Literature.

Although topical medical therapy and selective-laser-trabeculoplasty represent the treatments of choice to reduce intraocular pressure, many patients do not achieve adequate glaucoma control; therefore, they require further options and eventually surgery. Trabeculectomy is still considered the gold standard, but the surgical management of glaucoma has undergone continuous advances in recent years, XEN-gel-stent has been introduced as a safer and less traumatic means of lowering intraocular pressure (IOP) in patients with open-angle glaucoma (OAG). This study aimed to review the effectiveness and safety of clinical data on XEN-stent in OAG patients with a Synthesis-Without-Meta-analysis (SWiM) methodology.

Efficacy and Safety of PreserFlo MicroShunt After a Failed Trabeculectomy in Eyes with Primary Open-Angle Glaucoma: A Retrospective Study.

Introduction: To evaluate the efficacy and safety of PreserFlo MicroShunt in primary open angle glaucoma (POAG) eyes after a single failed trabeculectomy.

Methods: Retrospective review of POAG eyes with a failed trabeculectomy that underwent PreserFlo MicroShunt implantation from March 2019 to November 2019, in two Italian glaucoma centers. Pre- and postoperative data were collected and compared.

Surgical alternative to trabeculectomy.

Non-penetrating glaucoma surgery, represented by deep sclerectomy and viscocanalostomy, is an effective method to lower intraocular pressure (IOP) in glaucomatous patients. Both procedures reduce IOP by allowing aqueous humor drainage without opening the anterior chamber. Deep sclerectomy, similar to trabeculectomy, provides aqueous external filtration in the subconjunctival space.

Criteria for choosing clinically effective glaucoma treatment: A discussion panel consensus.

Unlabelled: Abstract.

Background: In the clinical management of patients at risk for or diagnosed with primary open-angle glaucoma (POAG), the aim of medical treatment is to reduce intraocular pressure (IOP) and then maintain it over time at a level that preserves both the structure and function of the optic nerve.

Objective: The objective of this report was to establish a consensus on the criteria that should be used to determine the characteristics of IOP-lowering medication.

Failure of medical therapy despite normal intraocular pressure.

The disease glaucoma is now defined by characteristic optic disc and visual field change, without specific reference to the intraocular pressure (IOP). Success of treatment is no longer judged by the mere attainment of IOP less than 21 mmHg. Controversy remains, however, in deciding appropriate management where optic disc and/or visual field damage continues to progress despite a 'normal' IOP having been achieved with medical treatment.

An evaluation of the rate of nonresponders to latanoprost therapy.

Purpose: To determine the proportion of patients with primary open-angle glaucoma (POAG) or ocular hypertension (OH) who do not respond to latanoprost therapy.

Methods: Three hundred forty consecutive patients with a new diagnosis of POAG or OH, or previously treated only with a beta-blocker and after an appropriate washout period, were treated with latanoprost for 1 month and then divided into three groups on the basis of the reduction in intraocular pressure (IOP): nonresponders (<15%), responders (> or =15% but <30%), and high-responders (> or =30%). To give a wide picture of the drug effect, eight different cut-off points were used to present data on distribution of mean IOP reductions.

Gold standard medical therapy for glaucoma: defining the criteria identifying measures for an evidence-based analysis.

Background: Over the past decade, several new medical therapies have become available for the treatment of primary open-angle glaucoma (POAG). A systematic evidence-based approach for identifying an optimal therapeutic agent is lacking.

Objectives: The aims of this review were to critically evaluate published treatment recommendations for POAG and, based on a systematic review of the literature, to develop criteria that would define a "gold standard" medical therapy that reflects new treatment advances and established therapeutic goals.

Viscocanalostomy in rhesus monkeys.

Objective: To examine structural changes and aqueous humor outflow after viscocanalostomy in live normal monkey eyes.

Methods: Viscocanalostomy surgery was performed in 1 eye of each of 4 rhesus monkeys. Outflow facility was determined before and after surgery.

Viscocanalostomy in patients with glaucoma secondary to uveitis: preliminary report.

Purpose: To assess the efficacy of viscocanalostomy in eyes with uncontrolled glaucoma secondary to uveitis.

Setting: Immunology and Uveitis Service, Department of Ophthalmology and Visual Sciences, University Hospital San Raffaele, Milan, Italy.

Methods: All consecutive patients with glaucoma secondary to uveitis and inadequate intraocular pressure (IOP) control (IOP >21 mm Hg) under maximum-tolerated medical therapy had viscocanalostomy.

Viscocanalostomy versus trabeculectomy in white adults affected by open-angle glaucoma: a 2-year randomized, controlled trial.

Purpose: To compare the effectiveness and safety of viscocanalostomy and trabeculectomy in adults with uncontrolled open-angle glaucoma.

Design: Single-masked, parallel-group, prospective, randomized 24-month trial, with 90% power to detect a clinically important difference between groups.

Participants: Fifty consecutive patients (50 eyes) with primary open-angle or pseudoexfoliative glaucoma.

Treatment of hyperfiltering blebs with Nd:YAG laser-induced subconjunctival bleeding.

Purpose: To assess the feasibility of a new technique to manage hyperfiltering blebs after penetrating glaucoma surgery.

Methods: Neodymium:yttrium-aluminum-garnet (Nd:YAG) laser bursts were used to induce bleeding in conjunctival and episcleral vessels in the bleb area to achieve local delivery of autologous blood.

Results: In the three cases reported here in which this technique was used, the treatment was successful and safe, leading to resolution of hypotony and reduction of the bleb with no complications.

Viscocanalostomy: a pilot study.

Purpose: Viscocanalostomy is a new, non-penetrating procedure for glaucoma surgery. We started a prospective study to assess the effectiveness and safety of the operation. Materials and methods.

Nd:YAG laser iridotomy in pigment dispersion syndrome: an ultrasound biomicroscopic study.

Aims: Ultrasound biomicroscopy was used to study the shape of the iris and the iridolenticular contact in pigment dispersion syndrome (PDS) eyes, to compare them with matched normal eyes, and to assess the morphological effects of laser iridotomy in PDS eyes.

Methods: 50 eyes of 50 patients suffering from PDS (group 1), and 15 normal eyes of 15 subjects matched for age and refraction (group 2), were studied by ultrasound biomicroscopy (UBM, Humphrey-Zeiss). Nd:YAG laser iridotomy was proposed to the 30 PDS patients with concave iris and 18 underwent the treatment.

Value of ultrasound biomicroscopy for ciliodestructive procedures.

Ciliodestructive procedures are commonly performed by the transscleral approach because ciliary processes are seldom visible. Thus the ablative energy is directed toward an "invisible" target whose position can only be estimated on the basis of experimental data. Ultrasound biomicroscopy has been recently introduced in ophthalmologic practice.

Contact transscleral cyclophotocoagulation with diode laser in refractory glaucoma.

Objective: To evaluate the clinical effectiveness of contact transscleral cyclophotocoagulation (CTCP) with diode laser.

Design And Patients: Forty-eight seeing eyes and 20 blind and painful eyes of 68 patients suffering from refractory glaucoma were treated using a diode laser (EOS3000, Laser Science) coupled with a 400-microns optic fiber ending in a 3-mm focusing tip. Sixteen to twenty 3.

Diode and Nd:YAG laser contact transscleral cyclophotocoagulation in a human eye: a comparative histopathologic study of the lesions produced using a new fiber optic probe.

We compared the contact cyclodestructive effects (both gross and histologic) achieved with diode and Nd:YAG laser wavelengths (810 and 1064 nm, respectively), using equivalent energy doses, released by means of a new optical delivery system in a human eye that was soon to be enucleated because of a choroidal melanoma. For both lasers, a fiber optic system (400 microns) with a focusing microlens placed at the end of the fiber was used. The center of the beam was placed 1.

Diode laser compared with argon laser for trabeculoplasty.

A randomized prospective study on two groups of ten patients compared the efficacy of diode laser and argon laser trabeculoplasty. In the diode laser group the intraocular pressure was 23.0 +/- 3.

Increased preferential optic disc asymmetry in ocular hypertensive patients compared with control subjects.

The authors determined asymmetrical differences in optic disc cupping and pallor between the right and left eyes of 57 control subjects and 75 patients with ocular hypertension. Photogrammetry was used to measure the optic disc cup, and computerized image analysis was used to measure the optic disc pallor for the total disc and its quadrants. Generally, for control and ocular hypertensive eyes, the median values of cupping and pallor were significantly larger in the left eye than in the right, except for depth in the inferior quadrant (right eye minus left eye = 9.