Publications by authors named "Cara T Khayat"
Article Synopsis
- GRID1 and GRID2 are genes that encode proteins essential for the organization and development of synapses in the central nervous system, with variations linked to neurodevelopmental issues.
- The study analyzed human variants from various sources, finding many variants in intolerant domains that could disrupt normal protein function, particularly in the amino terminal and M3 transmembrane domains.
- Experiments showed that certain variants lead to dysfunction in receptor interaction and activity, with pentamidine effectively inhibiting hyperactive GluD2 variants, highlighting the importance of these receptors in both healthy function and disease contexts.
Purpose: Limited research exists on the time course of long-term retinal and cerebral deficits in diabetic rodents. Previously, we examined short term (4-8 weeks) deficits in the Goto-Kakizaki (GK) rat model of Type II diabetes. Here, we investigated the long-term (1-8 months) temporal appearance of functional deficits (retinal, cognitive, and motor), retinal vascular pathology, and retinal dopamine levels in the GK rat.
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