Impact of Supplementation and Nutritional Interventions on Pathogenic Processes of Mood Disorders: A Review of the Evidence.

This narrative review was conducted using searches of the PubMed/Medline and Google Scholar databases from inception to November 2019. Clinical trials and relevant articles were identified by cross-referencing major depressive disorder (and/or variants) with the following terms: folate, homocysteine, S-adenosylmethionine (SAMe), L-acetylcarnitine, alpha-lipoic acid, N-acetylcysteine, L-tryptophan, zinc, magnesium, vitamin D, omega-3 fatty acids, coenzyme Q10, and inositol. Manual reviews of references were also performed using article reference lists.

Relevance of exclusion criteria in antidepressant clinical trials: a replication study.

Introduction: Patients in clinical randomized controlled trials (RCTs) of antidepressants are different from those typically treated in clinical practice, which may affect the generalizability of data from RCTs. We attempted to replicate the work of Zimmerman and colleagues (Zimmerman M, Mattia JI, Posternak MA. Are subjects in phamacological treatment trials of depression representative of patients in routine clinical practice? Am J Psychiatry.

Rational antidepressant selection: applying evidence-based medicine to complex real-world patients.

Every clinician faces the daily question of which antidepressant is best for a particular depressed patient. Double-blind studies submitted for U.S.