Publications by authors named "Cara M Kenney"
Background: Although most malignancies express cancer-testis antigens (CTA), immune responses to these proteins are limited in thoracic oncology patients. This trial was undertaken to examine if a cancer cell lysate vaccine could induce immunity to CTA, and to ascertain if metronomic cyclophosphamide and celecoxib enhances vaccine-induced immune responses.
Methods: Eleven patients with primary thoracic malignancies and 10 patients with extrathoracic neoplasms metastatic to the chest rendered NED by conventional therapies were randomized to receive H1299 lung cancer cell lysates (10 mg protein/vaccine) with Iscomatrix™ adjuvant via deep intradermal injection q 4 weeks ×6 with or without daily oral metronomic cyclophosphamide/celecoxib.
Article Synopsis
- This study aimed to investigate and characterize the rheumatological issues associated with GATA2 deficiency by reviewing cases and conducting assessments on selected patients.* -
- Out of 157 patients analyzed, 28 (17.8%) displayed various rheumatological symptoms, with many experiencing these symptoms before or coinciding with their GATA2 diagnosis; notable conditions included joint hyperextensibility and early onset osteoarthritis.* -
- The findings suggest that individuals with GATA2 deficiency often experience immune dysregulation, as evidenced by changes in T cell populations, and underline the need for further understanding of the rheumatological complications associated with this condition.*
Background: Esophageal cancers accounted for nearly 16,000 deaths in 2016. The number of patients with esophageal cancers increases every year. Neoadjuvant chemoradiotherapy (nCRT) prior to esophagectomy is a standard treatment for esophageal cancers.
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